- Study conducted by
Moores Cancer Center atUniversity of California San Diego to evaluate safety and efficacy of mitazalimab injected intratumorally at the time of surgical irreversible electroporation (IRE) - Preclinical data suggest combination of IRE with CD40 agonism can generate systemic anti-tumor effects
- Mitazalimab demonstrated significant survival benefit in combination with mFOLFIRINOX over standard of care in OPTIMIZE-1 Phase 2 study in first-line metastatic pancreatic cancer
The NCI-funded Phase 1a/1b single-center study will enroll up to 18 patients, who will receive a single intratumoral injection of mitazalimab immediately after the surgical IRE, a form of non-thermal ablation that is currently in clinical use for selected patients with LAPC. The study is being conducted by researchers at
"The preclinical data generated in our lab shows that the combination of IRE with an antibody that stimulates the CD40 receptor improves the response to IRE and inhibits metastatic tumor growth," said
"Intratumoral delivery of immunotherapy is gaining increased importance, and in the setting of localized disease provides an opportunity to efficiently activate the immune cells in the tumor microenvironment. In this investigator-initiated study, we are looking forward to evaluating the combination of mitazalimab administered directly into the tumor alongside IRE," said Sumeet Ambarkhane, CMO of Alligator Bioscience. "The strong clinical data generated by mitazalimab over the last 12 months have received a great amount of interest from the scientific and medical communities. We are very pleased that an accomplished center of clinical excellence, such as
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[1] Conroy et al., N Engl J Med 2011; 364:1817-1825; DOI: 10.1056/NEJMoa1011923
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