Amicus Therapeutics : 1Q24 Earnings Deck FINAL

A T T H E F O R E F R O N T O F

T H E R A P I E S F O R R A R E D I S E A S E S

1Q24 Results

Conference Call &

Webcast

May 9, 2024

Forward-Looking Statements

This presentation contains "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995 relating to preclinical and clinical development of our product candidates, the timing and reporting of results from preclinical studies and clinical trials, the prospects and timing of the potential regulatory approval of our product candidates, commercialization plans, manufacturing and supply plans, financing plans, and the projected revenues and cash position for the Company. The inclusion of forward- looking statements should not be regarded as a representation by us that any of our plans will be achieved. Any or all of the forward-looking statements in this press release may turn out to be wrong and can be affected by inaccurate assumptions we might make or by known or unknown risks and uncertainties. For example, with respect to statements regarding the goals, progress, timing, and outcomes of discussions with regulatory authorities and pricing and reimbursement authorities, are based on current information. Actual results may differ materially from those set forth in this release due to the risks and uncertainties inherent in our business, including, without limitation: the potential that results of clinical or preclinical studies indicate that the product candidates are unsafe or ineffective; the potential that it may be difficult to enroll patients in our clinical trials; the potential that regulatory authorities may not grant or may delay approval for our product candidates; the potential that required regulatory inspections may be delayed or not be successful and delay or prevent product approval; the potential that we may not be successful in negotiations with pricing and reimbursement authorities; the potential that we may not be successful in commercializing Galafold® and/or Pombiliti® and Opfolda® in Europe, the UK, the US and other geographies; the potential that preclinical and clinical studies could be delayed because we identify serious side effects or other safety issues; the potential that we may not be able to manufacture or supply sufficient clinical or commercial products; and the potential that we will need additional funding to complete all of our studies, the manufacturing, and commercialization of our products. With respect to statements regarding corporate financial guidance and financial goals and the expected attainment of such goals and projections of the Company's revenue, non-GAAP profitability and cash position, actual results may differ based on market factors and the Company's ability to execute its operational and budget plans. In addition, all forward-looking statements are subject to other risks detailed in our Annual Report on Form 10-K for the year ended December 31, 2023, and on Form 10-Q for the quarter ended March 31, 2024, to be filed today. You are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof. All forward-looking statements are qualified in their entirety by this cautionary statement, and we undertake no obligation to revise or update this news release to reflect events or circumstances after the date hereof.

Non-GAAP Financial Measures

In addition to financial information prepared in accordance with U.S. GAAP, this presentation also contains adjusted financial measures that we believe provide investors and management with supplemental information relating to operating performance and trends that facilitate comparisons between periods and with respect to projected information. These adjusted financial measures are non-GAAP measures and should be considered in addition to, but not as a substitute for, the information prepared in accordance with U.S. GAAP. We typically exclude certain GAAP items that management does not believe affect our basic operations and that do not meet the GAAP definition of unusual or non-recurring items. Other companies may define these measures in different ways. When we provide our expectation for non-GAAP operating expenses on a forward-looking basis, a reconciliation of the differences between the non-GAAP expectation and the corresponding GAAP measure generally is not available without unreasonable effort due to potentially high variability, complexity and low visibility as to the items that would be excluded from the GAAP measure in the relevant future period, such as unusual gains or losses. The variability of the excluded items may have a significant, and potentially unpredictable, impact on our future GAAP results.

2

A Rare Company

A leading biotech company projected to deliver 2024 total revenue growth of 25%-30%1

>500 EMPLOYEES in 20+ Countries

LEVERAGEABLE	2
GLOBAL
COMMERCIAL	APPROVED
ORGANIZATION	THERAPIES

13-17%

FY 2024 Galafold

Revenue Growth1

First Two-Component Therapy

for Pompe Disease

World Class

Clinical

Development

Capabilities

Guiding to Full

Year 2024

Non-GAAP Profitability

25-30%

FY 2024 Total

Revenue Growth1

Combined Peak

Revenue Potential

$1.5B - $2B

3	1At CER: Constant Exchange Rates

2024 Strategic Priorities

1. Transformative Year Ahead for Amicus

1

2

3

4

Galafold® revenue growth of 11-16% at CER1, now raised to 13-17%

Execute multiple successful launches of Pombiliti® + Opfolda®

Advance ongoing studies to support medical and scientific leadership in Fabry and Pompe diseases

Achieve non-GAAP profitability for the full year

4	1CER: Constant Exchange Rates; 2024 Galafold revenue guidance utilizes actual exchange rates as of December 31, 2023
4

Galafold® (migalastat)

Continued Growth

Building a leadership position in the treatment of Fabry disease

5

2024 Galafold Success (as of March 31, 2024)

Galafold is the only approved oral treatment option in Fabry disease

A unique mechanism of action for

Fabry patients with amenable variants

Galafold is indicated for adults with a confirmed diagnosis of Fabry disease and an amenable variant. The most common adverse reactions reported with Galafold (≥10%) were headache, nasopharyngitis, urinary tract infection, nausea, and pyrexia. For additional information about Galafold, including the full U.S. Prescribing Information, please visit https://www.amicusrx.com/pi/Galafold.pdf. For further important safety information for Galafold, including posology and method of administration, special warnings, drug interactions, and adverse drug reactions, please see the European SmPC for Galafold available from the EMA website at www.ema.europa.eu.

$99.4M

1Q24 Galafold

>60% Revenue

Share of Treated

Amenable Patients

2,400+

Individuals

Treated 40+

Countries with

Regulatory

Approvals

13-17%

2024 Galafold Growth at CER1

35-50%

Fabry Patients

Amenable to

Galafold

6	1At CER: Constant Exchange Rates

Galafold Performance

Q1 2024 Galafold reported revenue growth of +16% at CER to $99.4M

$438M-$454M1

$388M

 Global mix of switch (~42%) and previously

$329M

$107M

untreated patients (~58%)2

$306M

Q4

 Expect non-linear quarterly growth to continue

$261M

due to uneven ordering patterns and FX

Q3

fluctuations

$182M

$101M

Distribution of Galafold revenue

Q2

by quarter over previous 5 years:

$91M

$94M

Q1

Q2

Q3

Q4

Q1

$37M

Q1

5 Year Avg.

22%

24%

26%

28%

$99M

$5M

$86M

FY16

FY17

FY18

FY19

FY20

FY21

FY22

FY23

FY24

Raising FY 2024 Galafold growth guidance to 13%-17% at CER

7	1At CER: Constant Exchange Rates
2Data on file

Key Growth Drivers for 2024

Highest patient demand in last four years lays strong foundation for continued double-digit Galafold

growth in 2024

• Expanding market through uptake in naïve population as well as geographic and label expansion
• Increasing patient identification through ongoing medical education, screening, and improved diagnostics
• Driving market share of treated amenable patients through excellent execution
• Maintaining >90% adherence and compliance through HCP and patient education and support

88

Pombiliti® (cipaglucosidase alfa-atga)

+

Opfolda® (miglustat)

Potential to establish a new standard of care for people living with late-onset Pompe disease

9

Pombiliti + Opfolda Performance

Q1 2024 revenue of $11M, up +30% from Q4 2023, provides strong foundation for 2024

$62M-67M1

$11M

Q1

$11M

FY23FY24

Guiding to $62M to $67M in FY 2024 Pombiliti + Opfolda Revenue1

10	1At CER: Constant Exchange Rates