Annexin Pharmaceuticals announced that its drug candidate ANXV has been granted enhanced and extended patent protection by the US Patent and Trademark Office. The United States Patent and Trademark Office (USPTO) has approved another of the company's patent applications protecting the drug candidate ANXV, a recombinant human Annexin A5 protein currently being evaluated in a phase 2 clinical trial in the eye disease retinal vein occlusion. The now granted composition of matter patent is a protection that completely new chemical substances can be expected to receive, but is rarely granted for proteins that are almost identical to the body's own.

In addition, the USPTO grants an extension of the patent protection to 2039. Annexin Pharmaceuticals has several previously approved patents, including in the United States, for the process used to produce the drug candidate ANXV. The patents also cover ANXV-like proteins, chemical modification of such proteins and their medical use.

ANXV is produced using so-called recombinant technology, which means that the gene for the human protein Annexin A5 is incorporated into the gene set of a carefully selected bacterial strain. The bacteria can thus produce large amounts of ANXV, which is then purified in several steps so that the product can be used in clinical studies or other applications.