On February 17, 2023, Chids Mahadevan notified Applied Therapeutics, Inc. that he will resign from his position as the Company's Vice President of Finance and interim Principal Financial Officer, effective as of February 24, 2023, to pursue another professional opportunity. In connection with his departure, Mr. Mahadevan will be entitled to receive payment of his discretionary cash bonus with respect to 2022, subject to a customary release of claims. The Company has appointed Steven Ortega, Chief Accounting Officer, as the interim Principal Financial Officer, effective immediately, in light of Mr. Mahadevan's anticipated departure.