Arrowhead Pharmaceuticals, Inc. appointed Patrick O'Brien, age 59, as Chief Operating Officer and General Counsel effective as of July 15, 2022. Mr. O'Brien will also continue to perform the functions of Chief Compliance Officer and Corporate Secretary. Mr. O'Brien joined the Company in December 2014, and prior to his appointment as Chief Operating Officer and General Counsel was serving in the role of General Counsel, Corporate Secretary, and Chief Compliance Officer.

Mr. O'Brien has practiced in the healthcare legal field for over 25 years. Before joining the Company, from 2012 to 2014, Mr. O'Brien was with Shire, as global pharmaceutical company, where he was Group Vice President, Law. Immediately prior to working with Shire, he was a partner with the international law firm of Holland & Knight LLP in its Washington, DC office.

In 2010, Mr. O'Brien co-founded the law firm O'Brien Gould PLLC which joined Holland & Knight in 2011. From 2009 to 2010, Mr. O'Brien was a partner in Burke O'Neil LLC. From 2001 to 2009, Mr. O'Brien served in several legal roles with Johnson & Johnson, including serving as Vice President of Law for J&J's Centocor Ortho-Biotech unit.

Mr. O'Brien previously served as Regulatory Counsel with the United States Food & Drug Administration. Mr. O'Brien was awarded a BS in Pharmacy and a PharmD from the University of Arizona before completing a residency in Clinical Pharmacy with the University of Illinois at Chicago Hospital. He was also awarded his JD from the University of Arizona.