Athira Pharma, Inc. presented new preclinical data supporting the potential therapeutic benefit of fosgonimeton for the treatment of Alzheimer's disease (AD) and other neurodegenerative diseases at the Society for Neuroscience (SfN) Annual Meeting 2023, being held in Washington, D.C. from November 11 - 15, 2023. Fosgonimeton is a potentially first-in-class, small-molecule, brain-penetrant positive modulator of the neurotrophic hepatocyte growth factor (HGF) system with the potential to protect and repair neuronal networks. Fosgonim Princeton is a small molecule designed to enhance the activity of the neurotrophic HGF system, an endogenous repair mechanism for a healthy nervous system.

The function of the neurotrophicHGF system may be impaired in conditions of neurodegeneration. Targeting the protection and repair of neuronal networks, fosgonimeton has disease-modifying potential to address a broad range of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Dementia with Lewy bodies.