BRAIN Group

Pioneering Bioproducts

Analyst Call

FY 2019/'20

Adriaan Moelker, CEO

Lukas Linnig, CFO

Zwingenberg, January 14th ,2021

Pioneering Bioproducts.

© BRAIN Aktiengesellschaft Zwingenberg Germany www.brain-biotech.com +49 (0) 6251-9331-0

1

Safe Harbor Statement

This document may contain forward-looking statements. These forward-looking statements are subject to risks and uncertainties, as they relate to future events and are based on current assumptions of the Company, which may not occur at all in the future or may not occur as assumed. They do not represent a guarantee for future results or performance of the Company, and the development of economic and legal conditions may materially differ from the information expressed or implied in the forward-looking statements.

The Company assumes no obligation to update or revise any forward-looking statement contained herein or to adapt them to future events or developments. The information contained in this document has not been independently verified. No representation or warranty expressed or implied is made as to, and no reliance should be placed on, the fairness, accuracy, completeness or correctness of the information or opinion contained herein. The Company or any of its shareholders, affiliates, advisors, employees or representatives shall have no liability whatsoever (in negligence or otherwise) for any loss arising from any use of this document or its content or otherwise arising in connection with this document.

By accepting this presentation you acknowledge that you will be solely responsible for your own assessment of the market and the market position of the Company and that you will conduct your own analysis and be solely responsibility for forming your own view of the potential future performance of the Company's business.

This presentation speaks as of January 14th, 2021. Neither the delivery of this presentation nor any further discussions of the Company with any of the recipients shall, under any circumstances, create any implication that there has been no change in the affairs of the Company since such date. The term "BRAIN", as used in this presentation means B.R.A.I.N. Biotechnology Research and Information Network AG and its affiliates, if not otherwise specified.

Pioneering Bioproducts.

© BRAIN Aktiengesellschaft Zwingenberg Germany www.brain-biotech.com +49 (0) 6251-9331-0

2

This is BRAIN

BRAIN AG

BioScience

BioIndustrial

Solutions & Services

Products

Breakthroughs

Stable Service Business with Upside

Innovation & Optimization

Incubator/NBD

TMS

BioActive Compound Libraries

Enzymes

Microorganisms

Bioactives

~ €5m-€7m Annual

~ €13m Annual Revenues*

~ €25m Annual Revenues

Cost-plus Contract research,

Investment

~10% adj. EBITDA Margin*

Milestones, Technology & License Fees

*FY '19/'20

Pioneering Bioproducts.

© BRAIN Aktiengesellschaft Zwingenberg Germany www.brain-biotech.com +49 (0) 6251-9331-0

3

Plant-Based Sweetener: JDA with Roquette

From the DOLCE research program to market introduction

Research phase successfully completed

  • Dolce research program successfully completed
  • One lead candidate selected: Brazzein, plant-based protein sweetener
  • Focus: beverage industry which uses ~70% of the sugar consumed
  • Additional candidates discovered which allows development for further applications with freedom to operate

Commercialization starting

  • JDA between BRAIN and Roquette signed
  • Upscale production and approval process
  • Highly potent GRAS microorganism for the biological production of the sweetener developed by BRAIN
  • Already commercially viable yields at laboratory scale
  • Strong interest and support by several large beverage companies
  • Market introduction in 3-4 years ("novel food" EFSA and FDA approval)

Pioneering Bioproducts.

© BRAIN Aktiengesellschaft Zwingenberg Germany www.brain-biotech.com +49 (0) 6251-9331-0

4

The Sweetener

Strong market potential

Market Potential

  • Targeted at the largest market segment: beverages
  • Can also be used for additional applications
  • Strong consumer support: all natural plant-based sweetener
  • High industry need: health concerns on sugar and artificial sweeteners, sugar tax

Superior Properties

  • Taste very close to natural sugar, no dominant off-taste
  • Taste 1000-2000 times sweeter than sugar
  • Almost calorie free and not cariogenic
  • High solubility in water
  • Full biotechnology production process: no mono-plantations or arable land usage
  • Can be expressed in a GRAS microorganism at commercially viable yields and high quality
  • GMO free end product

Pioneering Bioproducts.

© BRAIN Aktiengesellschaft Zwingenberg Germany www.brain-biotech.com +49 (0) 6251-9331-0

5

Our Incubator: Focused New Business Pipeline**

rNPV

Profit

Market

Model

R&D

Pipeline

Partners

R&D

Market

Potential

Options

Platform

*1

*2

*3

3-5 years out

1-3 years out

In pre-launch

Natural fermented beverages 1

Small

Prod, Fee,

M/O

MSP

Salt taste enhancer 1.0

US-CPGC

Small

Fee, MSP,

B/A

Lic

Natural fermented beverages 2

JP.Bev

Large

Prod,

M/O

MSP, Prof

Perillic Active, Anti-Microbial

Med

B/A

ND

Prod, Prof

Gold from waste streams

Med

Prod, Fee,

M/O

Prof

DOLCE Natural Sweet Solutions

Large

Fee, MSP,

B/A, E/P

Aurase

Large

Prof, Lic,Prod

Fee,

E/P

Prod, Prof

Current

Project

Status

(!was)

**

  • Projects Green Metal Mining, Sweet Taste Enhancer and CO2 moved to TMS business, fully funded programs
  • Projects Salt-E, Fresco shelved, searching for partners
  • New enzymes now part of BioIndustrial regular product development, see page 12
  • Programs without contractually bound partners are marked red by default
  • Contractual, technology or registration hurdles still need attention
  • Phase 1 has been successfully completed but contract negotiations for the next development phase are progressing but not yet finalized

*1: BRAIN-Group rNPV FCF+TV: Small< €5M , Medium €5M - €15M, Large: €15M+

*2: Prod: Product sales. Fee: Research Fee income. MSP: Milestone Payments. Lic: License/royalty payments Tec: Tech fees Prof: Entity formation or Profit participation

*3: B/A: BioActives,E/P: Enzymes and Proteins, M/O: Microorganisms/Starter cultures

ND: not disclosed

Pioneering Bioproducts.

© BRAIN Aktiengesellschaft Zwingenberg Germany www.brain-biotech.com +49 (0) 6251-9331-0

6

Current Management Focus

  • Prepare organization for future growth and profitability
  • Introduce new organizational structure
    • Focus Business Development (Sales)
  • Business prioritization in the new business development pipeline
  • Performance manage group companies
  • Build M&A pipeline
  • Execute bolt-on value enhancing M&A transactions
  • Enzyme host organism optimization & development
  • Secure new public R&D Funding
  • Introduce group benchmarking and best-practice transfer
  • Upgrade HR process: performance management & talent development
  • Create a sustainability report, prepare organization for ESG reporting
  • Centralizing of corporate functions over the mid-term

Accomplished In progress

Pioneering Bioproducts.

© BRAIN Aktiengesellschaft Zwingenberg Germany www.brain-biotech.com +49 (0) 6251-9331-0

7

Financial Highlights at a Glance

Organic

Organic

12M

12M

Growth

Growth

Q4

Q4

Growth

Growth

Comment

(in € thousand)

2019/20

2018/19

2019/20

2018/19

Revenues

38,225

38,560

-0.9%

3.4%

8,671

10,626

-18.4%

-18.4%

12M milestones €640K

BioScience

13,230

12,192

8.5%

8.5%

2,754

4,572

-39.8%

-39.8%

(PY:€792K)

BioIndustrial

25,081

26,411

-5.0%

1.0%

5,954

6,090

-2.2%

-2.2%

Total operating performance (1)

39,238

41,231

-4.8%

-1.0%

8,928

11,526

-22.5%

-23.1%

€629K ESOP, €222K M&A/Integration

Adjusted EBITDA (2)

-2,018

-2,167

6.9%

-52.2%

-1,465

-96

-1422.5%

-13562.7% €1007K Board Changes / Corona Bonus

EBITDA

-3,876

-2,496

-55.3%

-67.4%

-2,970

-234

-1170.7%

-1809.2%

EBIT

-8,229

-7,198

-14.3%

-17.7%

-4,718

-993

-375.0%

-419.3%

Net Result

-9,017

-11,119

18.9%

17.2%

-2,910

-3,151

7.7%

5.1%

Operating Cash Flow

-4,767

-3,380

-41.0%

-40.4%

967

1,513

-36.1%

-36.1%

30.09.2020

30.09.2019

Cash

18,943

15,160

25.0%

25.9%

Number of Employees

279

281

-0.6%

2.3%

Material Expense Ratio

43.6%

45.1%

- 1.6%

PP.

- 1.8%

PP.

Adj. Personnel Expense Ratio

46.3%

45.0%

1.3%

PP.

3.2%

PP.

  1. Revenues + change in inventories + other income + R&D grants
  2. The full reconciliation from adjusted to unadjusted EBITDA can be found in the appendix

Major Events FY '19/'20:

  • Group: so far only limited Covid-19 effects materialized
  • Organic growth despite the pandemic
  • Dynamic overall FY BioScience business despite weak Q4
  • BioIndustrial organic growth suppressed by Covid-19, phasing and relocation issues
  • Reduced adjusted EBITDA loss YoY
  • EBITDA burdened by one-off charges (management changes)
  • Successful cash capital increase, approximately:1.8mio shares and proceeds of ~EUR15 mio
  • Minority buy-out of WeissBioTech generates potential to accelerate synergies and restructure (closed July 1st,2020)
  • Adriaan Moelker new CEO from February 1st
  • Lukas Linnig new CFO from October 1st
  • New ambitious mid-term targets communicated at the CMD

Pioneering Bioproducts.

© BRAIN Aktiengesellschaft Zwingenberg Germany www.brain-biotech.com +49 (0) 6251-9331-0

8

Strong Long-Term Revenue Growth Trajectory

BRAIN Revenues History

45 Mio. €

40 Mio. €

-1%

**

42%

35 Mio. €

12%

30 Mio. €

6%

25 Mio. €

20 Mio. €

38,6

38,2

15 Mio. €

22,8

24,1

27,1

10 Mio. €

21,1

10,4

*

**

5 Mio. €

8,8

Mio. €

FY 12/13

FY 13/14

FY 14/15

FY 15/16

FY 16/17

FY 17/18

FY 18/19

FY 19/20

YOY Growth

*purchase BioCatalysts Ltd. **divesture Monteil Cosmetics

Pioneering Bioproducts.

© BRAIN Aktiengesellschaft Zwingenberg Germany www.brain-biotech.com +49 (0) 6251-9331-0

9

Improving Adjusted EBITDA

Adjusted EBITDA 12M 19/20

4.000

3.000

2.805

2.528

2.000

1.000

0 €

T.

-1.000 €

In

-2.000 €

-2.167

-2.018

-3.000 €

-4.000 €

-5.000 €

-4.541

-4.932

-6.000 €

BRAIN Group

BioScience

BioIndustrial

18/19 - 19/20

18/19 - 19/20

18/19 - 19/20

Group adj. EBITDA improved by 6.9% YoY; driven by the segment BioScience which has been able to further reduce its EBITDA loss

The BioIndustrial segment had a constant adj. EBITDA margin of ~10%; (excluding inventory write-downs of 11.3%)

BioIndustrial organic growth suppressed by

Covid-19, phasing and relocation issues;

mainly driven by WeissBioTech

Pioneering Bioproducts.

© BRAIN Aktiengesellschaft Zwingenberg Germany www.brain-biotech.com +49 (0) 6251-9331-0

10

Cash & Cash Flow

Solid Cash Position

12M

12M

Growth

Q4

Q4

Growth

(in € thousand)

2019/20

2018/19

2019/20

2018/19

Comment

Gross Cash Flow

-6,056

-6,257

3.2%

-1,446

-1,361

-6.3%

Operating Cash Flow

-4,767

-3,380

-41.0%

967

1,513

-36.1%

strong working capital reduction PY

Investing Cash Flow

-4,469

-6,743

33.7%

79

-2,222

103.6%

Financing Cash Flow

13,093

-276

4841.9%

-821

473

-273.7%

~14.6 mio net proceeds capital increase

Net change in Cash & Cash

Equivalents

3,857

-10,400

137.1%

225

-237

195.2%

30.09.2020

30.09.2019

Cash

18,943

15,160

25.0%

Equity

26,143

20,172

29.6%

Pioneering Bioproducts.

© BRAIN Aktiengesellschaft Zwingenberg Germany www.brain-biotech.com +49 (0) 6251-9331-0

11

M&A: BioSun, A First Bolt-On Acquisition

Improved Group US distribution network

The Transaction

  • Florida, US, based successful distributor, formulator and blender
  • Established brand name
  • Industry leading flavors, custom blended enzymes, colors and specialty ingredients
  • Own in-house analytical and pilot application laboratory
  • Low to mid-single digit million USD sales, profitable since inception
  • Purchased directly from the owner at favorable terms
  • Deal closed on January 1st, 2021

Advantages to BRAIN

  • Increasing our product footprint in the US
  • Strengthening of our US distribution, can be utilized by all group companies
  • Nation-widecustomer network especially among small/mid-sized F&B companies
  • BioSun adds regulatory skills for the US market
  • BRAIN group can add formulation and blending know how to accelerate growth
  • Complementary to Biocatalysts and WeissBioTech
  • Profitable already today within the BioIndustrial margin with the potential to lift additional cost and revenue synergies
  • Immediately accretive

Pioneering Bioproducts.

© BRAIN Aktiengesellschaft Zwingenberg Germany www.brain-biotech.com +49 (0) 6251-9331-0

12

Covid-19 Update

Secure:

Targets:

Measures:

Health aspects

Safety of employees

Covid-19 task force

Supply chain

Business continuity

Hygiene concept

Operating business

Minimize disruptions

Personal safety supplies

Future pipeline

Fulfill customer contracts

Physical distancing

Home office

Strict travel restrictions

Flex work

Digitalize workflow

Current Disruptions: SolasCure is facing around 6-9 months delays in clinical trials as the relevant test centers have been closed for non Covid-19 patients. Lower sales volumes of enzyme products to ethanol and wine producers

Future Challenge: travel restrictions and physical distancing make it more challenging to visit customers for new projects (BioScience). Our business development team is working here with creative solutions and trying its best to keep effects on the commercial project pipeline as low as possible

Summary:

BRAIN Group: so far only small negative Covid-19 effects materialized. Effects on FY '20/21 currently hard to forecast and quantify.

Pioneering Bioproducts.

© BRAIN Aktiengesellschaft Zwingenberg Germany www.brain-biotech.com +49 (0) 6251-9331-0

13

Our Targets

This FY

  • Qualitative Guidance:
    • Potential Covid-19 and Brexit effects currently hard to forecast
    • Improvement of our EBITDA and operating cash flow targeted
    • Significantly lower amount of one-off charges forecasted
    • as stated at our CMD: overall organic growth likely to be below the mid-term average (high base BioScience, solid BioIndustrial expected despite addressed challenges at WeissBioTech)
    • On enzyme products, where sales volumes are negatively affected by Covid-19: we focus on margin protection
  • Quantitative guidance:
    • Will be issued latest with the Q2 results due to today's uncertainties related of the Covid-19 pandemic

Mid-Term, Unchanged (4-5 years)

  • Double group revenue from base '18/19
    • Double digit topline product CAGR
    • Accretive M&A
    • Contract research "TMS" proportionally reduced (excl. milestones)
  • Group adj. EBITDA margin 15% (+/- 5PP)
    • Double digit fermentation production volume of customized novel enzymes
    • Mid single digit annual productivity improvements
  • Proportion of new product sales: ~30% of total revenues
    • Continuous innovation pipeline management

Pioneering Bioproducts.

© BRAIN Aktiengesellschaft Zwingenberg Germany www.brain-biotech.com +49 (0) 6251-9331-0

14

Our Share Ownership*

DAH

Beteiligungs

GmbH

6.6%

Lloyd Fonds

4.3%

Free Float

Founders/

Management

9.6%

43.5%

36.0%

MP

Beteiligungs-

GmbH

Current number of shares: 19,861,360 Free float of ~ 45%

Strong long-term investor base

  • 8,000 shareholders

WKN 520394 / ISIN DE0005203947

Symbol BNN

Prime Standard; Frankfurt/M

*September 30th, 2020

Pioneering Bioproducts.

© BRAIN Aktiengesellschaft Zwingenberg Germany www.brain-biotech.com +49 (0) 6251-9331-0

15

Financial Calendar

QUARTERLY STATEMENT

Publication of the quarterly statement as of December 31st, 2020 (3M)

February 26th, 2021

ANNUAL GENERAL MEETING

Annual General Meeting (FY 2019/20)

March 10th, 2021

QUARTERLY STATEMENT

Publication of the quarterly statement as of March 31st, 2021 (6M)

May 28th, 2021

QUARTERLY STATEMENT

Publication of the quarterly statement as of June 30th, 2021 (9M)

August 30th, 2021

Pioneering Bioproducts.

© BRAIN Aktiengesellschaft Zwingenberg Germany www.brain-biotech.com +49 (0) 6251-9331-0

16

Thank you for your attention.

BRAIN Aktiengesellschaft

Darmstädter Straße 34-36

64673 Zwingenberg, Germany www.brain-biotech.com

Your contacts:

Michael Schneiders, Head of IR

+49 (0) 6251-9331-86MiS@brain-biotech.com

Martina Schuster, IR

+49 (0) 6251-9331-69MS@brain-biotech.com

@BRAINbiotech

BRAIN AG

Pioneering Bioproducts.

© BRAIN Aktiengesellschaft Zwingenberg Germany www.brain-biotech.com +49 (0) 6251-9331-0

17

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BRAIN - Biotechnology Research And Information Network AG published this content on 14 January 2021 and is solely responsible for the information contained therein. Distributed by Public, unedited and unaltered, on 14 January 2021 08:17:05 UTC