BRAIN Biotech AG ("BRAIN") has successfully demonstrating genome editing activity in mammalian cell lines with its proprietary CRISPR-Cas genome editing nucleases BRAIN-Metagenome-Cas (BMC), BRAIN-Engineered-Cas (BEC). This is expected to pave the way to potentially employ BRAIN's genome editing technology in large addressable markets such as animal livestock, pharmacology and therapeutics. The company will continue to develop this technology jointly with partners for a magnitude of end markets and applications.

These BRAIN-developed genome-editing nucleases are already successfully employed in customer projects within the BioScience division and are utilized for the optimization of highly efficient microbial producer strains which power the biological production in so called microbial cell factories. Together with partners this proprietary genome editing nucleases are currently advanced for applications in agriculture, pharmaceutical cell lines, marine applications and industrial producer strains. BRAIN-Engineered-Cas (BEC) and BRAIN-Metagenome-Cas (BMC) are different types of nucleases which differ in their general protein structure and their mode of action to target DNA.

Hence, they can address different markets and applications most effectively. In July 2021 BRAIN had announced the identification of around 2,000 so far untapped additional Class 2 CRISPR nucleases which have been identified in-silico and have the potential to be deployed for genome editing. BEC and BMC are the lead nucleases which are currently developed for genome editing in several applications.