- Two abstracts highlighting the Company's lead hepatitis B-focused asset will be presented as poster and oral presentations.
- More mature interim data to be presented at EASL following abstract data cuts earlier in the year may indicate potential rates of functional cure.
“We are pleased to present the latest data on our immunotherapeutic candidate, VTP-300, at EASL 2024 updated from the data cut we made in January for the abstracts,” said
Abstract Acceptances:
Abstract number: 2823
Presentation type: Poster presentation
Title: VTP-300 immunotherapeutic, plus low dose PD-1 inhibitor, nivolumab, continues to show meaningful, sustained reductions in HBsAg levels.
Presentation time: Wednesday, 05 June,
Authors: MF. Yuen, WL. Chuang, CJ. Liu, A. Leerapun, P. Tangkijvanich,
Key Findings: Preliminary data suggest VTP-300 in combination with nivolumab has been generally well tolerated, with no observed treatment-related serious adverse events, and contributed to declines in hepatitis B surface antigen (HBsAg) across all groups. Additional interim data, including NUC discontinuation, Hepatitis B Virus (HBV) markers, immunology and safety data will be presented in the poster.
Abstract number: 505
Presentation type: Oral presentation
Title: Imdusiran (AB-729) administered every 8 weeks for 24 weeks followed by the immunotherapeutic VTP-300 maintains lower HBV surface antigen levels in NUC-suppressed CHB subjects than 24 weeks of imdusiran alone.
Presentation time: Thursday, 06 June,
Authors:
Key Findings: Imdusiran administered for 24 weeks followed by VTP-300 was generally well-tolerated and resulted in lower HBsAG levels than placebo at week 60. Additionally, more subjects that received VTP-300 qualified to stop NUC therapy than placebo. On-treatment, follow-up and NUC discontinuation data including HBV parameters and immunology data will be included in the oral presentation.
About VTP-300
VTP-300 is an immunotherapeutic candidate consisting of an initial dose using the ChAdOx vector and a secondary dose(s) using the MVA vector, both encoding multiple hepatitis B antigens, including full-length surface, modified polymerase, and core antigens. VTP-300 is the first antigen-specific immunotherapy that has been shown to induce sustained reductions in HBsAg. Barinthus Bio is studying VTP-300 in combination with other agents, including siRNA and low-dose anti-PD-1 antibodies, to control the infection and counterbalance the immune suppression and T cell exhaustion in the liver caused by chronic HBV infection.
About HBV
Globally it is estimated that there are approximately 254 million people, including up to 2.4 million in the
About Barinthus Biotherapeutics
Barinthus Bio is a clinical-stage biopharmaceutical company developing novel T cell immunotherapeutic candidates designed to guide the immune system to overcome chronic infectious diseases, autoimmunity and cancer. Helping people living with serious diseases and their families is the guiding principle at the heart of Barinthus Bio. With a broad pipeline, built around three proprietary platform technologies: ChAdOx, MVA and SNAP, Barinthus Bio is advancing a pipeline of four product candidates across a diverse range of therapeutic areas, including: VTP-300, an immunotherapeutic candidate designed as a potential component of a functional cure for chronic HBV infection; VTP-200, a non-surgical product candidate for persistent high-risk human papillomavirus (HPV); VTP-1000, an autoimmune candidate designed to utilize the SNAP-Tolerance Immunotherapy (TI) platform to treat patients with celiac disease; and VTP-850, a second-generation immunotherapeutic candidate designed to treat recurrent prostate cancer. Barinthus Bio’s proven scientific expertise, diverse portfolio and focus on pipeline development uniquely positions the company to navigate towards delivering treatments for people with infectious diseases, autoimmunity and cancers that have a significant impact on their everyday lives. For more information, visit www.barinthusbio.com.
References
- WHO, Global hepatitis report 2024.
Hepatitis B Foundation , What is Hepatitis B?, 2023.
Forward Looking Statements
This press release contains forward-looking statements regarding Barinthus Bio within the meaning of the Private Securities Litigation Reform Act of 1995, as amended, which can generally be identified as such by use of the words “may,” “will,” “plan,” “forward,” “encouraging,” “believe,” “potential,” and similar expressions, although not all forward-looking statements contain these identifying words. These forward-looking statements include, without limitation, express or implied statements regarding: our product development activities and clinical trials, including timing for readouts of any interim data or next steps for any of our programs, including VTP-300, or the HBV003 and AB-729-202 trials, the tolerability or potential benefits of VTP-300, and our ability to develop and advance our current and future product candidates and programs. Any forward-looking statements in this press release are based on our management’s current expectations and beliefs and are subject to numerous risks, uncertainties and important factors that may cause actual events or results to differ materially from those expressed or implied by any forward-looking statements contained in this press release, including, without limitation, risks and uncertainties related to the success, cost and timing of our pipeline development activities and planned and ongoing clinical trials, our ability to execute on our strategy, regulatory developments, our ability to fund our operations and access capital, the risk that interim or topline data may not reflect final data or results, global economic uncertainty, including disruptions in the banking industry, the conflict in
IR contacts:
Christopher M. Calabrese
Managing Director
+1 917-680-5608
ccalabrese@lifesciadvisors.com
Managing Director
+1 617-283-2856
kgardner@lifesciadvisors.com
Media contact:
+1 917-519-9577
audrafriis@sambrown.com
Company contact:
IR & PR Manager
Barinthus Bio
ir@barinthusbio.com
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