BeyondSpring : DUBLIN-3 Topline Data

Plinabulin DUBLIN-3 NSCLC Topline Data

August 4 2021 | NASDAQ: BYSI

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Disclaimer

This presentation has been prepared for informational purposes only. No money or other consideration is being solicited, and if sent in response, will not be accepted. This presentation shall not constitute an offer to sell, or the solicitation of an offer to buy, any securities, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction. The Company is not under any obligation to make an offering. It may choose to make an offering to some, but not all, of the people who indicate an interest in investing. The information included in any registration statement will be more complete than the information the Company is providing now, and could differ in important ways.

This presentation and any accompanying oral commentary contain forward-looking statements about BeyondSpring Inc. ("BeyondSpring" or the "Company"). Forward- looking statements are based on our management's beliefs and assumptions and on information currently available to our management, including those described in the forward-looking statements and risk factors sections of the Company's 20-F filed on April 30, 2021 and other filings with the United States Securities and Exchange Commission (SEC).

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Plinabulin: First-in-Class, Selective Immunomodulating Microtubule- Binding Agent (SIMBA) - Potent Antigen Presenting Cell (APC) inducer

GEF-H1 activation2

Plinabulin1

Rho/ROCK

activation1

Microtubules

Neutrophil demargination7

Kill cancer

cells4

JNK activation2

Dendritic cell maturation2,3

Kill cancer cells2

Increase LSK cells;	Delay neutrophil
Accelerate neutrophil maturation5	apoptosis6

T cell activation2,3

Plinabulin Novel Target: Immune Defense Protein GEF-H1

Note: 1 La Sala et al., 2019 Chem. 2 Kashyap et al., 2019 Cell Reports. 3 Zhang et al., 2005 Mol Cell Biol. 4 Singh et al., 2011 Blood. 5 Suwa et al., 2000 Am J Physiol Heart Circ Physiol; Ghosh et al., 2018 ACR Annual Conference; Blayney	3
et al., Society of Leukocyte Biology. 6 Asensi et al., 2004 Infection and Immunity.

Plinabulin Induces Dendritic Cell Maturation (the most potent APC), a Key Step in Initiating Anti-cancer Durable Response

❷ Plinabulin	2	3	❸ Checkpoint Inhibitors
Stimulate maturation of dendritic			Optimize T cell response
cells to increase antigen
presentation
Dendritic cells are the most		1
important antigen-presenting cells

• Radiation/Chemotherapy/ Plinabulin

Release Tumor Antigens

For more potent anti-cancer effect

• + ❷ + ❸ → Optimal Immuno-Oncology Response

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Severely Unmet Medical Need - 2nd/3rd Line NSCLC, EGFR Wild Type

Efficacy

• Large patient population with limited treatment options

1. EGFR wild type: ~85% western NSCLC and ~70% of Asian NSCLC patients

Safety	o With immunotherapies moved to first line,
	Docetaxel-based therapies are the mainstay
	therapy

• 1. TKIs are worse than docetaxel1
• Docetaxel-basedTherapies (SOC)
• 1. Limited efficacy

1. >40% severe neutropenia

Since nivolumab was approved 6 years ago, no new agent with novel

mechanism has been approved in this indication.

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1 Lancet Oncol. 2013 Sep;14(10):981-8.