On November 28, 2023, Kenneth B. Lee, Jr. notified BioCryst Pharmaceuticals, Inc. (the ?Company?) of his intention to retire from the Board of Directors of the Company (the ?Board?), effective December 31, 2023. Prior to his retirement, Mr. Lee served as Chair of the Audit Committee of the Board and as a member of the Finance Committee of the Board. Mr. Lee cited no disagreement with the Board or management relating to the Company, its operations, policies, or practices.

The Company is grateful to Mr. Lee for his 12 years of service on the Board and appreciates his many contributions to the Company.