Item 1.01 Entry into a Material Definitive Agreement.

On November 24, 2021, C4 Therapeutics, Inc. (the "Company") and Columbia Massachusetts Arsenal Office Properties, LLC (the "Landlord") entered into a third amendment (the "Lease Amendment") to the Company's existing building Lease dated July 5, 2017, which relates to the Company's office and laboratories located at 490 Arsenal Way, Watertown, Massachusetts 02472. Pursuant to the Lease Amendment, the Company will lease an additional approximately 66,052 square feet of office and laboratory space in its current location, for a total of 111,611 square feet of office and laboratory space, such space to be used for research and development activities and as the Company's office headquarters. The Company's lease of the additional premises is expected to commence on January 1, 2022.

The term of the Lease Amendment will be 120 months from the commencement date. The Lease Amendment also serves to extend the current lease for the Company's initial premises to expire at the same time as the expiration date of the Lease Amendment. The Company will have an option to extend the Lease Amendment for one 60-month extension period at either in-place rent or determined pursuant to the Lease Amendment.

The Lease Amendment provides for the payment of basic rent for both the initial and the expansion premises, which amounts are subject to customary annual rent increases. Through the entry into the Lease Amendment, the Company has agreed to increase the rent payable in respect of the Company's existing premises, starting after the expiration of the original lease term for those premises on April 30, 2028. The aggregate basic rent payable under the Lease Amendment for both the initial and the expansion premises during the 120-month term is anticipated to be $104.8 million. In addition to the basic rent, the Company is also obligated to pay as additional rent its proportionate share of Landlord's operating expenses, including property taxes. The Lease Amendment requires the Company to deliver to the Landlord an updated and increased letter of credit.

The foregoing summary of the Lease Amendment is subject to and qualified in its entirety by the full text of the Lease Amendment, a copy of which is filed as Exhibit 10.1 to this Current Report on Form 8-K and is incorporated herein by reference.

Item 2.03 Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant.

The information contained in Item 1.01 of this Current Report on Form 8-K incorporated by reference into this Item 2.03.

Item 9.01 Financial Statements and Exhibits.

(d) Exhibits. The exhibits shall be deemed to be filed or furnished, depending on the relevant item requiring such exhibit, in accordance with the provisions of Item 601 of Regulation S-K (17 CFR 229.601) and Instruction B.2 to this form.





Exhibit
Number                                  Description
10.1        Lease Amendment, dated November 24, 2021, by and between C4
          Therapeutics, Inc. and Columbia Massachusetts Arsenal Office Properties,
          LLC
          Cover Page Interactive Data File (embedded within the Inline XBRL
104       document)

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