Cantargia presented interim efficacy data for 39 non-small cell lung cancer (NSCLC) patients treated with nadunolimab (CAN04) and platinum-based chemotherapy as a poster at the ASCO Annual Meeting 2023 (ASCO 2023), and on the Cantargia webpage. Efficacy of the combination therapy was well above historical data for chemotherapy alone, including two patients with complete response. The data presented at ASCO 2023 were communicated at the time of abstract release on May 25, 2023.

In summary, the results show strong efficacy of nadunolimab combined with platinum-based chemotherapy in 39 NSCLC patients. Efficacy for the total 30 first- or second-line NSCLC patients treated with this combination in the CANFOUR trial is summarized below, as reported May 25, 2023: Efficacy parameter, All (n=30), Historical control, Non-squamous (n=16), Non-squamous, historical control, Median OS, 13.7 mo, 10.3 mo, 15.9 mo, 11.3 mo, Median PFS, 7.0 mo, 5.1 mo, 7.3 mo, 4.9 mo, ORR, 53%, 22-28%, 56%, 19%, Complete response, 6.7% (n=2), <1%. Consistently high response rates to nadunolimab Combined with platinum doublets in different lines of therapy were also reported.

This includes a preliminary ORR of 60% in five first- or second-lineNSCLC patients with carboplatin/pemetrexed, and a preliminary ORR of 50% in four third-line or beyond NSCLC patients with cisplatin/gemcitabine.