On March 19, 2024, Dr. Joana Goncalves, the Chief Medical Officer of Cara Therapeutics, Inc. (the Company), informed the Company of her intention to resign from her role effective April 16, 2024, to pursue another opportunity. Dr. Goncalves will continue to serve as Chief Medical Officer through April 16, 2024, to assist with an orderly transition as her duties are assumed by other members of the senior management team. Dr. Goncalves's departure is not related to any disagreement with the Company.