Creo Medical : Letter to Shareholders

Creo Medical Group plc	Tel: [phone]
Creo House	Fax: [phone]
Unit 2, Beaufort Park	E-mail: [e-mail]
Beaufort Park Way	Website: www.creomedical.com
Chepstow, NP16 5UH
United Kingdom

4 June 2021

Dear Shareholder,

This letter is to notify you that the following documents ("Documents") have been published on the Company's website at https://creomedical.com/investors/reports-and-presentations:

1. Creo Medical Group plc's Annual Report & Accounts for the financial year ended 31 December 2020 (the "2020 Annual Report & Accounts"); and
2. a notice (the "Notice") of the Company's annual general meeting (the "AGM").

AGM

The AGM will be held on Wednesday, 30 June 2021 at 10:00 am at the offices of Osborne Clarke, 2 Temple Back East, Temple Quay, Bristol BS1 6EG.

This letter is a notification only and does not contain the specific details of the resolutions to be tabled at the AGM. The full details of the resolutions to be tabled at the AGM are contained in the Notice and should be read before you complete your vote.

The Directors consider that the resolutions to be proposed at the AGM are in the best interests of the Company and shareholders as a whole and unanimously recommend that you vote in favour of them.

COVID-19

The Directors recognise the vast improvement to the UK's COVID situation, however in light of the Company's ongoing desire to protect the health and safety of our shareholders and employees, the Directors recommend shareholders to not attend the AGM in person but vote via proxy.

Any shareholders wishing to attend the meeting in person are asked to confirm their attendance by emailing [e-mail] no later than 5.00 pm on Friday, 25 June 2021. All attendees will be required to follow all relevant COVID-19 safety procedures whilst on site. Should the number of shareholders who notify us of their intention to attend the meeting in person result in our needing to make alternative arrangements to ensure that we can accommodate them safely, then this will be notified to shareholders via the regulatory news service.

The General Meeting will comprise only the formal votes on each resolution as set out in the Notice, without any business update or Q&As. Voting will be conducted on each resolution by way of a poll.

All shareholders are invited to submit questions on the resolutions to be proposed at the AGM electronically before the AGM and such questions, limited to matters relating to the business of the AGM itself, should be sent to [e-mail] by no later than 5.00 pm on Friday, 25 June 2021 and these will be responded to on an individual basis.

Any questions raised, together with answers to them, will be published on the Company's website at https://creomedical.com/ investors/reports-and-presentations by 5.00 pm on Monday, 28 June 2021.

Proxy voting

Shareholders are urged to vote by proxy at the AGM. This can be done in the following ways:

• by completing, signing the enclosed Form of Proxy and returning it to Equiniti; or
• in the case of CREST members, by utilising the CREST electronic proxy appointment service.

Proxy votes must be received no later than 10:00 am on Monday, 28 June 2021.

Shareholders are recommended to appoint the Chair of the meeting as their proxy rather than a named person, as any such other person may not be permitted to attend the AGM in the event of unforeseen circumstances (e.g. if they are required to self isolate).

If there are any questions please contact Equiniti's Shareholder helpline on 0371 384 2030 ([phone] if calling from overseas). Lines are open between 8.30am and 5.30pm Monday to Friday excluding public holidays in England and Wales.

Charles Spicer

Chairman

Creo Medical Group plc

VAT registration number: 260 0226 55

Company registration number: 10371794

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