Two New Studies Presented at the American Heart Association Scientific Sessions 2021, Adoption of Technology Reported as “Excellent” and “Valuable” by Lead Authors
“This data adds to the growing body of evidence from other recently published studies demonstrating how the BVA-100 blood test uniquely allows physicians to characterize and better manage heart failure,” said
In heart failure, physicians seek to optimize a patient’s blood volume which has wide variations in total blood volume (TBV), plasma volume (PV) and red blood cell volume (RBCV). Phenotyping these derangements, or variations, and accurately detecting anemia are priorities for successful patient care. This study shows that measuring with blood volume analysis (BVA) distinct phenotypes have emerged, which provides clinicians with actionable information to achieve optimal fluid management.
The first study, titled, “Blood Volume Analysis Phenotypes in Heart Failure Patients with Left Ventricular Assist Device,” showed that wide total blood volume derangements are seen in LVAD patients up to 64 months post LVAD placement. Anemia persists in 50% of patients and polycythemia (excess of red cells) is present in 9% of patients, both of which are prognostic, or an advance indication, in a heart failure diagnosis.
Lead study author Dmitry M. Yaranov, M.D.,
The second study presented titled “True Anemia in Heart Failure Patients: Peripheral Hematocrits Lack Sensitivity and Specificity as a Predictor of Measured Red Blood Cell Volumes in a Mixed-LVEF Cohort,” examined three hematocrit (Hct) thresholds in a cohort of 245 heart failure patients for determining true anemia as measured by BVA. The data showed that Hct lacks sensitivity and specificity for detecting true anemia.
Anemia detection and treatment has become a priority in new approaches to heart failure management with as many as 62% of patients thought to suffer from anemia, often undetected with commonly used metrics such as hematocrit and hemoglobin measures and therefore untreated. “Interventions for anemia in heart failure would benefit from BVA,” commented
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