On November 13, 2022, Eric Francois resigned from the board of directors of Diffusion Pharmaceuticals Inc. and all committees and subcommittees thereof, effective as of December 16, 2022. Mr. Francois currently serves as a member of the Board's Audit and Compensation Committees. Mr. Francois indicated that his decision to resign was a result of certain mandatory internal policies and procedures of his current employer following a return to his investment banking career in late 2021, and was not the result of any disagreement with the Company, the Company's management or the Board.