Effective as of the close of business on May 15, 2023, Mr. William K. Hornung departed Diffusion Pharmaceuticals Inc. (the “Company”). Mr. Hornung had served as Diffusion's Chief Financial Officer since September 2018. In connection with Mr. Hornung's departure, the Company entered into a separation letter agreement and release with Mr. Hornung, dated as of May 15, 2023.