Emyria Limited announce positive progress on its MDMA analogue development program being run in partnership with the University of Western Australia (UWA). 16 of 17 compounds sent from the second batch of analogues successfully passed screening with Eurofins at the test concentrations, meaning these compounds showed no evidence of interactions with one or more of the enzymes or cell receptors ("anti-targets") that can be
associated with unwanted clinical side effects. These positive results bring the total count of successfully screened MDMA analogues to date to 83 out of 85. Additional preclinical screening is now being planned with a leading CRO who will perform a number of assays to evaluate the solubility, partition coefficients and metabolic stability of each compound. These assays can help to predict absorption and brain uptake rates and
help identify compounds that are similar to MDMA in potency but with faster onset and shorter half-lives, which may be more suitable for clinical applications. Leading MDMA analogues will undergo more sophisticated pharmacokinetic studies, which
is important in helping select compounds for further in vivo efficacy studies.