STORM will now use INDiGO, Evotec's unique integrated, accelerated IND-enabling platform, to progress STC-15 towards an IND application in 2021.
STORM discovered STC-15, an orally bioavailable, small molecule inhibitor of the enzyme METTL3 targeting modulation of RNA epigenetics, an entirely new mechanism of action, to treat acute myeloid leukaemia ('AML') and other solid and haematological cancers with the support from Evotec's pre-clinical drug discovery engine.
STORM leads the global field of RNA modulation having demonstrated in vivo proof of concept activity of the first RNA methyltransferase inhibitor in relevant animal models for myeloid and solid tumours. METTL3 is one of two programmes from the STORM platform that have already shown in vivo activity.
Dr
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About RNA, RNA epigenetics and STC-15
There is a growing understanding of the importance of RNA modifications in the development of cancer and other diseases, providing a wealth of novel therapeutic targets for drug discovery. STORM has used state-of-the-art drug discovery capabilities, combined with unique analytical technologies specifically developed to target RNA epigenetics, to generate highly potent selective and orally bioavailable, small molecule inhibitors of METTL3 and other RNA-modifying enzymes.
ABOUT STORM THERAPEUTICS
STORM Therapeutics, founded in 2015, is a
STORM is backed by blue chip investors
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