On March 31, 2022, James Pennington, M.D., Chief Medical Officer of First Wave BioPharma, Inc. (the 'Company'), informed the Company of his intention to retire as Chief Medical Officer. Dr. Pennington's notice did not relate to any disagreement with the operations, policies or practices of the Company on any matters. Dr. Pennington will transition to a consultant role until a new Chief Medical Officer has been appointed.