On September 28, 2023, Fulcrum Therapeutics, Inc. notified Mel Hayes, Fulcrum?s current chief operating officer (and principal operating officer) that it was eliminating his position effective October 2, 2023, following which, Fulcrum does not have a principal operating officer. Mr. Hayes agreed to remain with Fulcrum as its Executive Vice President, Patient Experience, and in connection therewith, entered into an amended and restated employment agreement reflecting his new role and title at Fulcrum. Such amended and restated employment agreement, which has a 12-month term, did not modify Mr. Hayes?

current compensation or severance arrangements.