Item 5.02 Departure of Directors or Certain Officers; Election of Directors;


          Appointment of Certain Officers; Compensatory Arrangements of Certain
          Officers.

On December 17, 2020, Ionis Pharmaceuticals, Inc. (the "Company") issued a press release announcing that its founder and executive chairman Stanley T. Crooke, M.D., Ph.D., will retire from the Company and its board of directors effective June 2021. Dr. Crooke is stepping down so that he may focus on his scientific interests and the nonprofit organization he founded, the n-Lorem Foundation.

Pursuant to a consulting agreement, Dr. Crooke will continue to serve as a scientific advisor to the Company including providing advice regarding the Company's research and development programs and guiding the core antisense research group he founded at the Company.

A copy of the release is attached as Exhibit 99.1 to this Current Report and incorporated herein by reference.



Item 9.01. Exhibits.



(d) Exhibits.

Exhibit No.   Description

   99.1       Press Release dated December 17, 2020.

    104       Cover Page Interactive Data File (embedded within the Inline XBRL
              document).

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