iRhythm Technologies, Inc. announced that the results of the KP-Rhythm2 study, titled “Diagnostic yield, outcomes and resource utilization with different ambulatory electrocardiographic monitoring strategies,” were published in the American Journal of Cardiology(AJC). While earlier peer-reviewed studies have found Zio XT to be better than Holter and event monitors in the detection of arrhythmias, the KP-Rhythm2 study, led by Kaiser Permanente and supported by a research grant from iRhythm Technologies, Inc., is the first study to address specifically Zio XT patch vs. a 30-day event monitor yielding similar diagnostic yield for atrial fibrillation (AF)/atrial flutter (AFL) =30 seconds in a general population of adults without known prior AF/AFL.

The KP-Rhythm2 study examined the efficacy of Zio XT, Holter monitors, and event monitors. It was designed to assess diagnostic yield, outcomes, and resource utilization by monitoring modality in individuals without previously documented AF or AFL. Zio XT was associated with significantly higher documentation1 of AF/AFL -related supraventricular tachycardias and non-sustained ventricular tachycardia than both 24-hour Holter and 30-day event monitoring.

In addition, the results of the Brady-TAVR study, titled “Bradyarrhythmias detected by extended rhythm recording in patients undergoing transcatheter aortic valve replacement,” were published in Heart Rhythm Journal in November 2021. The study aimed to determine the prevalence of bradyarrhythmias among patients undergoing transcatheter aortic valve replacement (TAVR) and whether pre- and post-TAVR extended rhythm monitoring with Zio XT would aid in the prediction of conduction disturbances and permanent pacemaker (PPM) implantation risk. Guidelines from the Journal of the American College of Cardiology (JACC) recommend that ECG monitoring be conducted pre- and post- TAVR, given the clinical importance of monitoring patients undergoing this procedure.

The study found that bradyarrhythmias can be detected with 14-day cardiac monitoring through Zio XT before and after TAVR.