Jupiter Neurosciences, Inc. announced topline proof-of-concept preclinical data with its proprietary resveratrol drug product, JOTROL™, for Parkinson's Disease (PD). In collaboration with scientists Shaun Brothers, PhD, MBA and Candace Carriere, PhD at the University of Miami School of Medicine, the Company recently completed preclinical activities in a validated mouse model of PD. This model of PD mimics many aspects of the disease utilizing a unilateral injection of a neurotoxin precursor that elicits nigral cell loss, striatal dopamine loss and behavior deficits similar to physiological characteristics of human Parkinson's disease.

Statistically significant positive outcomes, particularly in the endpoint of enhanced grip strength, has now been established in two preclinical indications, PD and MPSI. Grip strength is a key physical manifestation of the disease, a motor score used to measure the severity and progression of PD. Improvement of grip strength is a disease modifying breakthrough for patients suffering with Parkinson's. Additional findings include JOTROL™ significantly improving an outcome used to evaluate motor coordination, rotarod performance; significantly improving behavioral characteristics induced in the animal model; as well as being generally safe and well tolerated.

JOTROL, the Company's unique and patented platform product, is an enhanced orally administered resveratrol formulation designed to safely deliver therapeutically relevant levels of resveratrol. In a Phase I first-in-man trial, JOTROL™ was administered in ascending doses to assess safety, tolerability, and pharmacokinetics. JOTROL™ was determined to be safe and well tolerated at all dose levels administered and achieved blood plasma target levels 8-10-fold higher than naïve resveratrol administered in historical clinical trials.

These clinical studies were financed by a grant from the National Institute on Aging (NIA), entitled Safety and Pharmacokinetics of JOTROL for Alzheimer's Disease. Resveratrol has the ability to cross the blood-brain barrier and has demonstrated positive effects on oxidative stress, inflammation and mitochondrial function in Friedreich's ataxia (FRDA) and Alzheimer's disease (AD) patients.