Kaleido Biosciences, Inc. announced a research collaboration with researcher Robert Jenq, M.D. Professor of Genomic Medicine, at The University of Texas MD Anderson Cancer Center, to explore the potential of Kaleido’s novel Microbiome Metabolic Therapies (MMT™) in preventing febrile neutropenia—a serious complication associated with hematopoietic stem cell transplantations (HSCT). Approximately 60,000 patients undergo HSCT annually in the U.S. and Europe, which includes patients with myeloid disorders, lymphoid disorders and plasma cell disorders. Recent scientific findings have demonstrated that treatment regimens given to HSCT patients have a profound detrimental effect on their microbiome, putting them at increased risk of bacterial infections, febrile neutropenia and ultimately, graft-versus-host disease (GVHD). Within the collaboration, selected MMTs will be evaluated in disease animal models developed by Dr. Jenq, to further explore the molecular mechanisms by which MMTs act on the microbiome and gut barrier function and support the identification of a lead compound from Kaleido’s compound library.