Kodiak Sciences Inc. announced that data from tarcocimab tedromer will be presented during the annual meeting of the American Academy of Ophthalmology (AAO) to be held November 3-6, 2023 in San Francisco. During the Retina Subspecialty Day on November 3, 2023, detailed results will be presented for the first time from the Phase 3 GLOW study of tarcocimab tedromer in patients with non-proliferative diabetic retinopathy. In the pivotal GLOW study, all patients are randomized to receive either tarcocimab every six months after initiating doses given at baseline, 8 weeks and 20 weeks into the study, or to receive sham injections.

The Primary Endpoint was the proportion of tarcocimab-treated patients who experienced at least a 2-step improvement on the diabetic retinopathy severity scale (DRSS), a grading system measuring the degree of retinopathy, as compared to patients in the sham group. The Key Secondary Endpoint was the proportion of tarcocimab treated patients who suffered a sight threatening complication including progression to diabetic macular edema or proliferative diabetic retinopathy, as compared to patients in the sham group. Diabetic retinopathy (DR) is a common complication of diabetes that affects the eye.

If left untreated, diabetic retinopathy progresses and eventually can lead to serious vision-threatening complications, such as diabetic macular edema and proliferative diabetic retinopathy. It is estimated that of the 36 million American adults living with diabetes, 10 million have diabetic retinopathy. The Phase 3 GLOW study is a global, multi-center, randomized pivotal superiority study designed to evaluate the efficacy and safety of tarcocimab tedromer in treatment-naïve patients with moderately severe to severe non-proliferative diabetic retinopathy ("NPDR").

Patients are randomized to receive either tarcocimab every six months after initiating doses given at baseline, 8 weeks and 20 weeks into the study, or to receive sham injections. The primary endpoint is at one year. Outcomes include changes in diabetic retinopathy severity, measured on a standardized photographic grading scale, and the proportion of tarcocimab treated patients who developed a sight threatening complication due to diabetic retinopathy.