- Two poster presentations highlight Phase 1 data for LP352 in healthy volunteers
"At AAN, we are presenting data highlighting favorable safety, tolerability, pharmacokinetics and pharmacodynamics that were observed in our Phase 1 trial in healthy volunteers. Importantly, we saw adverse events consistent with expected effects of a serotonergic drug. 5-HT2c receptor engagement was demonstrated by dose- and exposure-dependent increase of prolactin," stated Dr.
Presentation Details:
Title: Single Ascending Dose Pharmacokinetics (PK), Pharmacodynamics (PD), and Tolerability of LP352 in Healthy Subjects (abstract #1750)
Session: P14: Epilepsy/Clinical Neurophysiology (EEG): ASM Clinical Trials 3
Date/Time:
Title: A Randomized, Double-Blind, Placebo-Controlled, Multiple Ascending Dose Pharmacokinetics (PK), Pharmacodynamics (PD), and Tolerability of LP352 in Healthy Subjects (abstract #1771)
Session: P14: Epilepsy/Clinical Neurophysiology (EEG): ASM Clinical Trials 3
Date/Time:
About LP352
LP352 is a highly selective, oral, centrally acting, next-generation 5-HT2c receptor superagonist in development for the potential treatment of seizures associated with developmental and epileptic encephalopathies (DEEs) such as Dravet syndrome, Lennox-Gastaut syndrome (LGS), tuberous sclerosis complex (TSC), CDKL5 deficiency disorder (CDD), and other epileptic disorders. LP352 is designed to modulate GABA inhibition and, as a result, suppress the central hyperexcitability that is characteristic of seizures. LP352 has demonstrated negligible observed impact on 5-HT2b and 5-HT2a receptor subtypes in the Company’s preclinical studies to date. 5-HT2b and 5-HT2a receptor agonism have been associated with significant adverse effects. LP352 has novel chemistry and attributes, and was designed to be more specific and selective for the 5-HT2c receptor subtype, giving it the potential to reduce seizures in DEE patients while overcoming the known or perceived safety limitations of available drugs in the 5-HT2 class. LP352 is currently being evaluated in the Phase 1b/2a PACIFIC Study in approximately 50 participants with a range of DEEs.
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Forward-Looking Statements
Certain statements in this press release are forward-looking statements that involve a number of risks and uncertainties. Such forward-looking statements include statements about Longboard’s participation in the upcoming meeting, clinical and preclinical programs, ability to develop medicines, and focus. For such statements, Longboard claims the protection of the Private Securities Litigation Reform Act of 1995. Actual events or results may differ materially from Longboard’s expectations. Factors that could cause actual results to differ materially from those stated or implied by Longboard’s forward-looking statements are disclosed in Longboard’s filings with the
Corporate Contact:Megan E. Knight Head of Investor Relations mknight@longboardpharma.com IR@longboardpharma.com 619.592.9775
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