Nanexa AB (publ) announced positive outcome in the first preclinical study with NEX-22. In a one-month study in rats, single doses of two different PharmaShell® formulations were studied in different doses. The results show a controlled release of liraglutide, with plasma exposure over 28 days for NEX-22, compared to around 2 days for a formulation with liraglutide without the PharmaShell coating.

The results will be confirmed in additional preclinical studies, in parallel with optimization of the formulation for a coming clinical phase 1 study of NEX-22. NEX-22 FOR TREATMENT OF TYPE 2 DIABETES One of the most common drug classes for the treatment of type 2 diabetes is GLP-1 (glucagon-like peptide-1) analogs, which are given subcutaneously once daily or once per week. Liraglutide is a GLP-1 analogue that is currently given by daily injections.

NEX-22 is a depot formulation of liraglutide with a monthly release that can replace today's treatment with daily or weekly injections of liraglutide and other GLP-1 analogues, which would give significant benefits with increased convenience and better compliance to treatment. Type 2 diabetes is a metabolic disease in which the body has difficult to regulate the sugar level in the blood, which leads to high blood sugar. The disease occurs mainly in upper middle age (>45 years), but the incidence increases in younger years because of an increasingly sedentary lifestyle and unhealthy diet.

Common symptoms include fatigue, increased thirst and frequent urination, while a non-compliant treatment can lead to serious sequelae. The treatment goal of type 2 diabetes is a lower blood sugar level, which is easy to measure.