Oncolytics Biotech Inc. announced the presentation of a poster that provides further positive translational data from the previously completed AWARE-1 breast cancer window-of-opportunity study, sponsored by SOLTI-Innovative Cancer Research, at the Society for Immunotherapy of Cancer (SITC) 38th Annual Meeting. Summary of Data and Findings for Expanded Translational Analysis of the AWARE-1 Study: Samples: From the AWARE-1 window-of-opportunity study of patients with early-stage HR+/HER2- breast cancer: Collected from cohort 2 patients who received pelareorep plus letrozole and atezolizumab (n=10); Tumor biopsies were collected on Day 1 (pretreatment), Day 3 (prior to atezolizumab) and Day 21 (when tumors were surgically removed). Evaluation process: Samples were evaluated using a biomarker panel of 37 conjugated antibodies that bind to tumor antigens and immune cells; The novel IMC technology was used to visualize cellular interactions down to the single cell level.

Results: Visualization of the data shows that pelareorep treatment changed the number of PD-L1 tumor cells and the architecture of the tumor microenvironment: By Day 3, an increase in PD-L1 positivity and cytotoxic T cells could be seen at a higher rate of tumor infiltration relative to baseline.