Oxford BioDynamics, Plc (AIM: OBD, the Company), a biotechnology company developing precision medicine tests for immune health based on the EpiSwitch 3D genomics platform, announces the initial results from an interim analysis conducted for the REFINE-ALS prospective trial.

The results from a subset of data, highlight the blood-based EpiSwitch prognostic stratification of patients with fast progressing Amyotrophic Lateral Sclerosis (ALS). The Phase 4 REFINE-ALS trial (NCT04259255)[1] is a prospective, multicenter study sponsored by Mitsubishi Tanabe Pharma America (MTPA) designed to identify biomarkers that could serve as quantifiable, biological and non-clinical measures of Edaravone's pharmacodynamic effect in ALS. To date, in the U.S., RADICAVA and RADICAVA ORS have been used to treat over 8,000 patients, with over 1.1 million days of therapy, and have been prescribed by nearly 2,000 HCPs].

ALS, also known as Lou Gehrig's disease in the US and motor neuron disease (MND) in the UK, is a terminal disorder that attacks nerve cells that control voluntary muscle movements, like chewing, walking, and breathing, usually leading to death from respiratory failure in 3-5 years[3]. Some patients exhibit fast disease progression, with shorter (

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