PacBio announced the creation of the HiFi Solves consortium. This global consortium brings together researchers from 15 leading genomics research institutions across 11 countries to study the value HiFi-based human genome sequencing may have in clinical research applications and to further understanding of genetic diseases. These institutions will collaborate to develop and share best practices on data generated from PacBio Revio sequencing systems, with the goal of leveraging the comprehensiveness and completeness of HiFi genomes in human genetics research applications.

PacBio HiFi long-read sequencing has the potential to become a single front-line assay for researchers interrogating rare disease cohorts because of its ability to call and phase all classes of variants accurately, unlike other technologies that require multiple assays. Through the HiFi Solves consortium, researchers will study the efficacy of HiFi sequencing in interrogating the many possible genetic mechanisms that underlie rare diseases. Members of the HiFi Solves Consortium will provide an overview of its goals and activities at the American Society of Human Genetics Annual Meeting in Washington D.C., and will share recent results, particularly around exploring potentially clinically relevant genes that lie in areas of high sequence homology or otherwise complex regions of the human genome.

Participating institutions of the HiFi Solves team are: Bioscientntia Institute for Medical Diagnostics (GmbH) (Germany); Broad Institute of MIT a Harvard (U.S.A.) Children's Hospital of Eastern Ontario (Canada); Children's Mercy Kansas City (U.S.A); Chulalongkorn University (Thailand); Hospital for Sick Children (SickKids) - (Canada); i-Lac (Japan); Karolinska University Hospital and Karolinska Institutet (Sw Sweden); KK Women's and Children's Hospital (Singapore); The Max Planck Institute for Molecular Genetics (Germany); Medizinische Universitt Innsbruck (Austria); National Center for Child Health and Development (Japan); Radboud University Medical Center (N Netherlands); SciLifeLab (Sw Sweden); University of Leuven (Belgium).