Patrys Limited announced new pre-clinical data for its lead asset, PAT-DX1. Results from a new study provide strong support for the continued development of PAT-DX1 to improve patient outcomes in high grade glioma (HGG), a fast growing and clinically challenging form of brain cancer. The study was conducted in the laboratory of Professor Terrence Johns of the Telethon Kids Cancer Centre.

The study showed that combining a therapeutic dose of standard radiation therapy (red bar) with 25mg/kg dose of PAT-DX1 (blue bar) increased median survival by 12 days (p<0.0002) compared to radiation treatment alone (n=10 per group). Additionally, even at a lower dose than previously used PAT-DX1 showed significant activity as a single agent, confirming previous studies in a range of brain cancers models. HGG is the most common and deadly type of brain cancer, affecting both adults and children.

Adult patients have a 5-year survival rate of 10% with standard therapy (surgical resection, radiation and chemotherapy). In children HGG is a rapid and universally lethal disease. HGG is called "high-grade" because the tumors are fast-growing and spread quickly through brain tissue making them very difficult to treat.