PetVivo Holdings, Inc. announced that the Company has released the results of a clinical study conducted by Inotiv, Inc., which examined the safety of intra-articular injections of a collagen-elastin hydrogel microparticulate biomaterial (that is Spryng? with OsteoCushion? Technology) into the joints of dogs.

SPRYNG with OsteoCushion Technology is an intra-articular injectable veterinary medical device consisting of sterilized, extra-cellular matrix microparticles. The microparticles of Spryng have been found to adsorb onto the joint synovial lining of animals and subsequently integrate with the animal?s subsynovial tissue. Such action promotes the restoration of proper joint mechanics, thereby aiding in the management of noninfectious sources of joint pain such as joint instability, degenerative joint disease and osteoarthritis.

The data provided from the dogs enrolled in this study demonstrates the excellent safety profile of Spryng when injected IA into 40 joints (10 each, stifle, elbow, shoulder, hip) across 20 individual dogs. Use of Spryng was similar to a benign control (saline) in regard to incidences of lameness, joint swelling, or pain after IA injection, and post-injection outcomes were most often no different than pre-injection baseline measures. To view the Technical Bulleton discussing the tolerability study involving the intra-articular injection of Spryng in the joints of dogs.