- Updated data from Phase 1 PYNNACLE clinical trial of PC14586 presented at 2023
AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics demonstrated responses across multiple tumor types with median duration of response of seven months - An overall response rate of 38% observed at the recommended Phase 2 dose of 2000 mg daily for the intended Phase 2 population of TP53 Y220C and KRAS wild-type patients
- Registrational Phase 2 clinical trial expected to initiate in Q1 2024
- Ongoing enrollment in the combination arm of the PYNNACLE study with PC14586 and KEYTRUDA® (pembrolizumab)
“We were very pleased to recently share updated Phase 1 data from our PYNNACLE clinical trial with the oncology community, demonstrating clinical efficacy and safety of PC14586 in heavily pretreated patients across multiple solid tumor types,” said
Third Quarter 2023 and Recent Corporate Highlights:
- Updated clinical results from the Phase 1 PYNNACLE study evaluating PC14586 were featured in a late-breaking poster at the 2023
AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics onOctober 12, 2023 . Confirmed responses were observed in patients whose tumors were TP53 Y220C and KRAS wild-type in the efficacious dose range, in multiple tumor types including ovarian, breast, prostate, small-cell lung, and endometrial cancer. An overall response rate of 38% was achieved at the Recommended Phase 2 Dose (RP2D) of 2000 mg daily (6/16 evaluable patients) reflective of the planned Phase 2 patient population (TP53 Y220C and KRAS wild-type). The median duration of response was seven months. A copy of the poster can be found on the PMV corporate website here. - The RP2D of 2000 mg once daily was selected based on overall safety, pharmacokinetics (PK), and efficacy in alignment with the
U.S. Food and Drug Administration (FDA) at an End of Phase 1 meeting held in Q3 2023. PMV plans to initiate a registrational tumor-agnostic Phase 2 clinical trial in early 2024. - The PYNNACLE clinical trial results were also highlighted in a KOL webinar which included a presentation by
Aparna Parikh , M.D, M.S., Director of the Global Cancer Care Program at Mass General Hospital Cancer Center. A copy of the webinar presentation can be accessed here. - Ongoing enrollment in the combination arm of PYNNACLE evaluating PC14586 with KEYTRUDA® (pembrolizumab). PMV and Merck entered into a collaboration in 2022 under the terms of which Merck is supplying KEYTRUDA for this study.
Third Quarter 2023 Financial Results
- During the nine months ended
September 30, 2023 , the Company raised$35.1 million in net proceeds through an At-the-Market facility (ATM). - PMV Pharma ended the third quarter with $238.1 million in cash, cash equivalents, and marketable securities.
- Net loss for the nine months ended September 30, 2023, was $53.2 million compared to $54.0 million for the nine months ended September 30, 2022.
- Research and development (R&D) expenses were $42.5 million for the nine months ended September 30, 2023, compared to $37.0 million for the nine months ended September 30, 2022. The increase in R&D expenses was primarily related to increased headcount and clinical expenses to advance research on PC14586, the Company’s lead drug candidate.
- General and administrative (G&A) expenses were $18.7 million for the nine months ended September 30, 2023, compared to $18.9 million for the nine months ended September 30, 2022. The decrease in G&A expenses was primarily due to facility-related costs now allocated to research as our new laboratory building in
Princeton, New Jersey began operations.
KEYTRUDA® (pembrolizumab) is a registered trademark of
About PMV Pharma
PMV Pharma is a precision oncology company pioneering the discovery and development of small molecule, tumor-agnostic therapies targeting p53. p53 mutations are found in approximately half of all cancers. The field of p53 biology was established by our co-founder Dr.
About PC14586
PC14586 is a first-in-class, small molecule, p53 reactivator designed to selectively bind to the pocket present in the p53 Y220C mutant protein, hence, restoring the wild-type, or normal, p53 protein structure and tumor-suppressing function. The
Forward-Looking Statements
Statements contained in this press release regarding matters that are not historical facts are “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995. Because such statements are subject to risks and uncertainties, actual results may differ materially from those expressed or implied by such forward-looking statements. Such statements include, but are not limited to, statements regarding the Company’s future plans or expectations for PC14586, including our ability to obtain approval on a tumor agnostic basis, expectations regarding timing of the Phase 2 portion of its current clinical trial for PC14586, expected therapeutic benefits of PC14586 including potential efficacy and tolerability, statements regarding the Company’s future plans or expectations for PC14586, including expectations regarding ongoing safety and response rate of participants in our clinical trials, timing for submission of a New Drug Application, as well as the overall success of current and future clinical trials for PC14586, and the adequacy of the data to support its regulatory approval, and any future commercialization plans for the product candidate. Any forward-looking statements in this statement are based on management’s current expectations of future events and are subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely from those set forth in or implied by such forward-looking statements. Risks that contribute to the uncertain nature of the forward-looking statements include: the success, cost, and timing of the Company’s product candidate development activities and planned clinical trials, the Company’s ability to execute on its strategy and operate as an early clinical stage company, the potential for clinical trials of PC14586 or any future clinical trials of other product candidates to differ from preclinical, preliminary, interim or expected results, the Company’s ability to fund operations, and the impact that the current COVID-19 pandemic will have on the Company’s clinical trials, supply chain, and operations, as well as those risks and uncertainties set forth in the section entitled “Risk Factors” in the Company’s Annual Report on Form 10-K filed with the
Investors Contact:
Chief Financial Officer
investors@pmvpharma.com
Media Contact:
kathy@greigcommunications.com
Condensed Balance Sheets (unaudited) (in thousands, except share and per share amounts) | ||||||||
2023 (unaudited) | 2022 | |||||||
Assets | ||||||||
Current assets: | ||||||||
Cash and cash equivalents | $ | 52,057 | $ | 108,297 | ||||
Restricted cash | 822 | 822 | ||||||
Marketable securities, current | 149,861 | 132,757 | ||||||
Prepaid expenses and other current assets | 2,556 | 5,130 | ||||||
Total current assets | 205,296 | 247,006 | ||||||
Property and equipment, net | 10,822 | 10,955 | ||||||
Marketable securities, noncurrent | 36,184 | 2,495 | ||||||
Right-of-use assets | 8,545 | 9,539 | ||||||
Other assets | 180 | 313 | ||||||
Total assets | $ | 261,027 | $ | 270,308 | ||||
Liabilities and Stockholders’ Equity | ||||||||
Current liabilities: | ||||||||
Accounts payable | $ | 1,678 | $ | 2,996 | ||||
Accrued expenses | 9,038 | 7,308 | ||||||
Operating lease liabilities, current | — | 528 | ||||||
Total current liabilities | 10,716 | 10,832 | ||||||
Operating lease liabilities, noncurrent | 12,699 | 13,448 | ||||||
Total liabilities | 23,415 | 24,280 | ||||||
Stockholders’ equity: | ||||||||
Additional paid-in capital | 532,214 | 487,516 | ||||||
Accumulated deficit | (294,247 | ) | (241,043 | ) | ||||
Accumulated other comprehensive loss | (355 | ) | (445 | ) | ||||
Total stockholders’ equity | 237,612 | 246,028 | ||||||
Total liabilities and stockholders’ equity | $ | 261,027 | $ | 270,308 |
Condensed Statements of Operations and Comprehensive Loss (unaudited) (in thousands, except share and per share amounts) | ||||||||||||||||
Three Months Ended | Nine Months Ended | |||||||||||||||
2023 | 2022 | 2023 | 2022 | |||||||||||||
Operating expenses: | ||||||||||||||||
Research and development | $ | 13,586 | $ | 13,666 | $ | 42,503 | $ | 36,963 | ||||||||
General and administrative | 6,042 | 5,709 | 18,727 | 18,915 | ||||||||||||
Total operating expenses | 19,628 | 19,375 | 61,230 | 55,878 | ||||||||||||
Loss from operations | (19,628 | ) | (19,375 | ) | (61,230 | ) | (55,878 | ) | ||||||||
Other income (expense): | ||||||||||||||||
Interest income, net | 2,984 | 1,124 | 8,005 | 1,830 | ||||||||||||
Other income (expense), net | 4 | 13 | 24 | 67 | ||||||||||||
Total other income (expense) | 2,988 | 1,137 | 8,029 | 1,897 | ||||||||||||
Loss before (benefit) provision for income taxes | (16,640 | ) | (18,238 | ) | (53,201 | ) | (53,981 | ) | ||||||||
(Benefit) provision for income taxes | — | (9 | ) | 3 | (9 | ) | ||||||||||
Net loss | (16,640 | ) | (18,229 | ) | (53,204 | ) | (53,972 | ) | ||||||||
Unrealized (loss) gain on available for sale investments, net of tax | (27 | ) | (2 | ) | 90 | (947 | ) | |||||||||
Comprehensive loss | $ | (16,667 | ) | $ | (18,231 | ) | $ | (53,114 | ) | $ | (54,919 | ) | ||||
Net loss per share -- basic and diluted | $ | (0.34 | ) | $ | (0.40 | ) | $ | (1.13 | ) | $ | (1.18 | ) | ||||
Weighted-average common shares outstanding | 49,047,296 | 45,622,957 | 46,889,921 | 45,556,635 |
Source:
2023 GlobeNewswire, Inc., source