Item 1.01. Entry into a Material Definitive Agreement.

On January 18, 2022, Sema4 Holdings Corp. ("Sema4" or the "Company") announced that it executed an Agreement and Plan of Merger and Reorganization (the "Merger Agreement") with GeneDx, Inc., a New Jersey corporation ("GeneDx"), and the other parties thereto (the transactions contemplated by the Merger Agreement, including the Mergers (as defined below), the "Acquisition"). This Current Report on Form 8-K provides a summary of the Merger Agreement and the other agreements entered into and contemplated in connection with the Acquisition. The descriptions of these agreements do not purport to be complete and are qualified in their entirety by the terms and conditions of such agreements, copies of which are attached as Exhibits 2.1, 10.1, 10.2, 10.3 and 10.4 hereto.

Merger Agreement

On January 14, 2022, Sema4 and its wholly-owned subsidiaries, Orion Merger Sub I, Inc. ("Merger Sub I") and Orion Merger Sub II, LLC ("Merger Sub II" and, together with Merger Sub I, "Merger Subs"), entered into the Merger Agreement with GeneDx, a wholly-owned subsidiary of OPKO Health, Inc. ("OPKO"), GeneDx Holding 2, Inc., which will own 100% of GeneDx at the Effective Time (as defined below) ("Holdco2"), and OPKO. Capitalized terms used but not otherwise defined herein will have those meanings ascribed to such terms in the Merger Agreement.

Acquisition

Pursuant to the terms of the Merger Agreement, Sema4 will acquire GeneDx through the merger of Merger Sub I with and into Holdco2 (the "First Merger"), with Holdco2 as the surviving corporation in the First Merger. Immediately after the consummation of the First Merger, as part of the same overall transaction, Holdco2, as the surviving corporation in the First Merger, will merge with and into Merger Sub II (the "Second Merger" and, together with the First Merger, the "Mergers"), with Merger Sub II as the surviving company. After giving effect to the Mergers and the other transactions contemplated by the Merger Agreement, GeneDx will have converted into a Delaware limited liability company and be a wholly-owned indirect subsidiary of Sema4. The Mergers are intended to qualify for federal income tax purposes as a tax-free reorganization under the provisions of Section 368(a) of the Internal Revenue Code of 1986, as amended.

The Acquisition was unanimously approved by the boards of directors of each of Sema4 and OPKO.

The Acquisition is expected to close in the first half of 2022, subject to the receipt of the required approval by Sema4's stockholders and the satisfaction of the closing conditions set forth in the Merger Agreement.

Merger Consideration

Subject to the terms and conditions of the Merger Agreement, Sema4 will pay consideration to OPKO for the Acquisition of (i) $150 million in cash at the closing of the Acquisition (the "Closing"), subject to certain adjustments as provided in the Merger Agreement (the "Cash Consideration"), (ii) 80 million shares of the Company's Class A common stock, par value $0.0001 per share ("Company Class A common stock") (the "Stock Consideration"), to be issued at the Closing and (iii) up to $150 million payable following the Closing, if certain revenue-based milestones are achieved for each of the fiscal years ending December 31, 2022 and December 31, 2023 (the "Milestone Payments"). Each Milestone Payment, if and to the extent earned under the terms of the Merger Agreement, will be satisfied through the payment and/or issuance of a combination of cash and shares of Company Class A common stock (valued at $4.86 per share based on the average of the daily volume average weighted price of Company Class A common stock over the period of 30 trading days ended January 12, 2022), with such mix to be determined in Sema4's sole discretion. The Milestone Payment in respect of the fiscal year ending December 31, 2023 is subject to acceleration on the terms described in the Merger Agreement.

The number of shares of Company Class A common stock that OPKO is entitled to receive as a result of the Mergers, as otherwise contemplated by the Merger Agreement, shall be adjusted to appropriately reflect the effect of any stock split, split-up, reverse stock split, stock dividend or distribution (including any dividend or distribution of securities convertible into Company Class A common stock), extraordinary cash dividend, reorganization,

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recapitalization, reclassification, combination, exchange of shares or other like change with respect to Company Class A common stock occurring on or after the date of the Merger Agreement and prior to the Closing.

Governance

In connection with the execution of the Merger Agreement, Katherine Stueland, the Chief Executive Officer of GeneDx, Kevin Feeley, the Chief Financial Officer of GeneDx, and Jennifer Brendel, the Chief Commercial Officer of GeneDx, have entered into employment agreements with Sema4, which will be effective upon the Closing. Following the Closing, Ms. Stueland will serve as the Co-Chief Executive Officer of Sema4, reporting to Sema4's Board of Directors (the "Board"), Mr. Feeley will service as Senior Vice President Operations, Sema4 and Head of GeneDx and Ms. Brendel will serve as Chief Growth Officer of Sema4.

Sema4 has agreed that OPKO will be entitled to nominate and Sema4 will seek to have appointed to the Board: (i) one mutually agreed GeneDx designee to the Board, initially Katherine Stueland, and (ii) one mutually agreed independent OPKO designee to the Board following the Closing and until at least the expiration of the milestone period, who will be identified in the proxy statement Sema4 intends to file with the Securities and Exchange Commission (the "SEC") and mail to its stockholders (the "Proxy Statement") in connection with Sema4 seeking certain stockholder approvals related to the Acquisition.

Representations and Warranties; Indemnification

The Merger Agreement contains customary representations and warranties of the parties and provides for mutual indemnification subject to customary limitations.

Sema4 Recommendation

Sema4 is required to include in the Proxy Statement the recommendation of the Board to Sema4's stockholders that they approve the transaction proposals (as such proposals are more fully set forth in the Merger Agreement).

Conditions to Closing

General Conditions

The obligations of either party to consummate the Acquisition are conditioned upon, among other things, (a) the approval of the issuance of the Stock Consideration by Sema4's stockholders, (b) the expiration or termination of the applicable waiting period under the Hart-Scott-Rodino Antitrust Improvements Act of 1976, as amended, and (c) the absence of any order or law making the consummation of the transactions illegal.

OPKO and the Company Parties' Conditions to Closing

The obligations of OPKO and the Company Parties' to consummate the Acquisition also are conditioned upon, among other things, (a) customary closing conditions, (b) the approval of the Stock Consideration for listing on the Nasdaq and (c) Sema4's having not suffered a material adverse effect.

Sema4 Conditions to Closing

The obligations of Sema4 to consummate the Acquisition are also conditioned . . .




Item 3.02.      Unregistered Sales of Equity Securities.

The disclosure set forth above in Item 1.01 of this Current Report on Form 8-K is incorporated by reference herein. The shares of Company Class A common stock to be issued pursuant to the Merger Agreement and the Subscription Agreements and the transactions contemplated thereby will not be registered under the Securities Act, and will be issued in reliance on the exemption from registration requirements thereof provided by Section 4(a)(2) of the Securities Act and/or Regulation D promulgated thereunder as a transaction by an issuer not involving a public offering. OPKO and the investors in the PIPE Investment have represented their respective intentions to acquire the shares for investment only and not with a view to or for sale in connection with any distribution, and appropriate restrictive legends will be affixed to the certificates representing all of the shares issued in the Acquisition and the PIPE Investment (or reflected in restricted book entry with the Company's transfer agent). The parties also had adequate access, through business or other relationships, to information about the Company.

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Item 5.02. Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers.

In connection with the Transactions, on January 14, 2022, the Board approved the appointment of Jason Ryan, a current director of the Company, as the Executive Chairperson of the Board, with such appointment to become effective as of January 18, 2022.

In addition, in connection with the Transactions, effective as of January 14, 2022, Keith Meister was appointed to the Board as a director of the Company (the "Director Appointment"). Following the Director Appointment, the Board consists of a total of ten directors, with Eli D. Casdin, Joshua Ruch and Michael Pellini as Class I directors of the Company whose terms expire at the Company's 2022 annual meeting of stockholders; Rachel Sherman, Eric Schadt, Nat Turner and Dennis Charney as Class II directors of the Company whose terms expire at the Company's 2023 annual meeting of stockholders; and Emily Leproust, Jason Ryan and Keith Meister as Class III directors of the Company whose terms expire at the Company's 2024 annual meeting of stockholders. In connection with Mr. Meister's appointment to the Board, he entered into an indemnification agreement with the Company in the form previously filed as Exhibit 10.4 to Sema4's Current Report on Form 8-K filed with the SEC on July 28, 2021 (the "July 28, 2021 8-K"). In connection with the appointment of Mr. Ryan as the Executive Chairperson of the Board, Mr. Ryan stepped down from his role as Chairperson of the audit committee and Mr. Meister was appointed to serve as the Chairperson of the audit committee.

There is no arrangement or understanding between Mr. Meister and any other persons pursuant to which Mr. Meister was selected as a director, and, except as described herein, there are no related party transactions involving Mr. Meister that are reportable under Item 404(a) of Regulation S-K, other than through his role as manager of Corvex Management LP ("Corvex"), a stockholder of the Company, and his former role as a member of the board of managers of CMLS Holding LLC (the "Former Sponsor"). The Company's prior transactions with Corvex and the Former Sponsor are described under "Certain Relationships and Related Party Transactions" beginning on page 304 of the Company's definitive proxy statement filed with the SEC on July 2, 2021, which description is incorporated herein by reference. In addition, Corvex has entered into a Subscription Agreement and a Support Agreement in connection with the Transactions. Further, Mr. Meister will receive compensation for his service on the Board consistent with the Company's standard compensation arrangements for non-employee directors.

The foregoing description of the form of indemnification agreement does not purport to be complete and is qualified in its entirety by reference to the full text of the form of indemnification agreement, a copy of which is attached as Exhibit 10.4 to the July 28, 2021 8-K and is incorporated herein by reference.

Item 7.01 Regulation FD Disclosure.

On January 18, 2022, Sema4 issued a press release announcing that it entered into the Merger Agreement described in Item 1.01 of this Current Report. A copy of the press release is furnished hereto as Exhibit 99.1. Furnished as Exhibit 99.2 hereto is an investor presentation, dated January 18, 2022, used by Sema4 regarding the Transactions. The information in this Item 7.01 and Exhibits 99.1 and 99.2 attached hereto shall not be deemed "filed" for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), or otherwise subject to liabilities under that section, and shall not be deemed to be incorporated by reference into the filings of Sema4 under the Securities Act or the Exchange Act, regardless of any general incorporation language in such filings. In the same press release, Sema4 also announced fiscal year 2022 guidance on revenue and resulting test volume.

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Item 9.01      Financial Statements and Exhibits.

(d) Exhibits.
     Exhibit
     Number                                          Description
      2.1  *        Agreement and Plan of Merger and Reorganization, dated as of January 14, 2022,
                  by and among, Orion Merger Sub I, Inc., Orion Merger Sub II, LLC, GeneDx, Inc.,
                  GeneDx Holding 2, Inc. and OPKO Health, Inc.
      10.1          Form of Subscription Agreement.
      10.2          Form of Shareholder Agreement.
      10.3          Form of Support     Agreement.
      10.4          Form of Lock-Up Agreement.
      99.1          Press Release issued by the Company on January     18,     2022.
      99.2          Investor Presentation of the Company dated January     18,     2022.
       104        Cover Page Interactive Data File (embedded within the Inline XBRL Document)

* The schedules and exhibits to the Agreement and Plan of Merger and Reorganization have been omitted from this filing pursuant to Item 601(a)(5) of Regulation S-K. Sema4 will furnish copies of any such schedules and exhibits to the Securities and Exchange Commission upon request.

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