Item 2.02 Results of Operations and Financial Condition. On November 15, 2021, Sema4 Holdings Corp. ("Sema4 Holdings" or the "Company") issued a press release (the "Press Release") and will hold a conference call announcing the Company's financial results for the three and nine months ended September 30, 2021. Copies of the Press Release and Earnings Presentation are furnished as Exhibits 99.1 and 99.2, respectively, to this Current Report on Form 8-K. The information furnished with this Item 2.02, including Exhibits 99.1 and 99.2, shall not be deemed "filed" for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), or otherwise subject to the liabilities of that section, nor shall it be deemed incorporated by reference into any other filing under the Securities Act of 1933, as amended, or the Exchange Act, except as expressly set forth by specific reference in such a filing.

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