Shionogi : Notice on the Selection to Apply to New Market Segment “Prime Market”on the Tokyo Stock Exchange

Press Release

Notice on the Selection to Apply to New Market Segment "Prime Market"

on the Tokyo Stock Exchange

OSAKA, Japan, 1, October, 2021 - Shionogi & Co., Ltd. (Head Office: Osaka, Japan; President and

CEO: Isao Teshirogi, Ph.D.; hereafter "Shionogi") received on July 9, 2021 the results of the initial assessment of its compliance with the listing standards of the new market segments to be introduced on April 4, 2022 from the Tokyo Stock Exchange, and confirmed its compliance with the listing standards for the "Prime Market".

Based on these results, at the Board of Directors Meeting held on August 30, 2021, Shionogi decided to select the new market segment "Prime Market" as its listing market and has therefore filed an application for inclusion in the "Prime Market" segment of the Tokyo Stock Exchange, Inc.

Forward-Looking Statements

This announcement contains forward-looking statements. These statements are based on expectations in light of the information currently available, assumptions that are subject to risks and uncertainties which could cause actual results to differ materially from these statements. Risks and uncertainties include general domestic and international economic conditions such as general industry and market conditions, and changes of interest rate and currency exchange rate. These risks and uncertainties particularly apply with respect to product-relatedforward-looking statements. Product risks and uncertainties include, but are not limited to, completion and discontinuation of clinical trials; obtaining regulatory approvals; claims and concerns about product safety and efficacy; technological advances; adverse outcome of important litigation; domestic and foreign healthcare reforms and changes of laws and regulations. Also for existing products, there are manufacturing and marketing risks, which include, but are not limited to, inability to build production capacity to meet demand, lack of availability of raw materials and entry of competitive products. The company disclaims any intention or obligation to update or revise any forward-looking statements whether as a result of new information, future events or otherwise.

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