Stoke Therapeutics announced that it has completed a $90 million Series B financing to advance its pipeline of antisense oligonucleotide medicines for Dravet Syndrome and other severe genetic diseases. The financing round was led by RTW Investments with participation from founding investor Apple Tree Partners. New investors include RA Capital Management, Cormorant Asset Management, Perceptive Advisors, funds managed by Janus Henderson Investors, Redmile Group, Sphera Funds Management, and Alexandria Venture Investments. Roderick Wong, M.D. from RTW Investments, Matthew Hammond, Ph.D. from RA Capital, and Bihua Chen from Cormorant Asset Management join the Board of Directors as observers. Stoke has identified thousands of genes that could be addressed by its proprietary TANGO technology, which targets non-productive RNA splicing to increase gene expression and address the root cause of monogenic diseases caused by loss or reduction of gene function. The company is rapidly advancing its lead program, a therapeutic candidate for Dravet Syndrome, and expects to be in the clinic by early 2020. Stoke has also built a robust pipeline of candidates targeting other diseases of the central nervous system, as well as diseases of the eye, ear, liver and kidney.