Tempest Therapeutics, Inc. announced that collaborators at the Beth Israel Deaconess Medical Center (BIDMC) at Havard Medical presented preclinical data at the American Association for Cancer Research (AACR) Annual Meeting demonstrating that TPST-1120 reduces kidney cancer (RCC) growth as a monotherapy, while also showing increased inhibition when combined with frontline chemotherapy and immunotherapy. These new data further support the clinical benefit observed in the TPST-1120 Phase 1 data presented in an oral presentation at ASCO 2022. Preclinical data presented at AACR showed that TPST-1120 increases infiltrating cytotoxic CD8+ T cells in the tumor microenvironment, consistent with modulation of the tumor microenvironment to a more immune responsive environment that allows for the influx of tumor specific CD8+ T cells.

In preclinical models of renal cell carcinoma (RCC), treatment with TPST-1120 reduced tumor growth by 52%-56% as monotherapy. Additional improvement in anti-cancer activity was demonstrated in combination treatment with standard first-line RCC cabozantinib or anti-PD1 therapy, where tumor inhibition was 81% and 74%, respectively. These data reinforce previously reported Phase 1 clinical data where objective responses were observed in patients with late line, immune refractory RCC treated with TPST-1120 and the immune therapy, nivolumab, and complement the positive Phase 1b/2 data reported in October 2023 from a global randomized study of TPST-1120 in combination with atezolizumab and bevacizumab in first-line patients with advanced HCC, which showed clinical superiority of the TPST-1120 arm over the control arm across multiple study endpoints and relevant biomarker-defined patient subpopulations.

TPST-1120 is an oral, small molecule, selective PPAR antagonist. In an ongoing global randomized phase 1b/2 study of TPST-1 120 in combination with atezolIZumab and bevacIZumab in first-line Patients with advanced HCC, the TPST-1 120 arm showed clinical superiority across multiple study endpoints when compared to atezolizumab & bevacizumab alone, the standard of care. These randomized data were supported by positive results observed in the Phase 1 clinical trial in patients with heavily pretreated advanced solid tumors.

TPST-1120 are wholly-owned by Tempest.