Todos Medical Ltd. announced that its CLIA/CAP-certified laboratory Provista Diagnostics has completed validation of a 27-pathogen urinary tract infection (UTI) PCR precision medicine panel. The assay is now in production, and the Company is preparing to launch it commercially. Provista intends to target skilled nursing facilities, ob/gyn and women's health specialists as primary customers.

The primary benefit of UTI testing using PCR, as compared with current standard methods of cell culture testing, is that PCR is much more sensitive in identifying all of the key bacterial pathogens involved in a UTI, as compared with cell culture that identifies primarily the most prevalent upon cell culture expansion (primarily e.coli). This e.coli pathogen overrepresentation leads to inappropriate therapy selection that results in poor outcomes for patients, including prolonged and worsening symptoms. The second benefit of PCR testing vs. cell culture for UTI, is the rapid turnaround time for (24h-48h) vs.

cell culture (3-7 days). For caregivers in skilled nursing facilities, in particular, the rapid identification and resolution of UTI is paramount to avoid potentially significant side effects including incontinence, agitation, lethargy, falls, urinary retention, decreased mobility, decreased appetite, fever, flushed skin, back pain, nausea and vomiting.