The board of directors of TOT BIOPHARM International Company Limited announced that Mr. Yao, Jau-Chang ("Mr. Yao") has resigned from his positions as joint company secretary of the Company and vice general manager of the finance management division of the Group due to his desire to pursue other career opportunities, with effect from 1 February 2022. Mr. Yao has confirmed that, as at the date of this announcement, he has no disagreement with the Board, and there are no other matters in relation to his resignation that need to be brought to the attention of the shareholders of the Company. The Board announced that Ms. Xiao, Ben ("Ms. Xiao"), senior director of the finance management division of the Group, has taken over Mr. Yao's finance-related functions, and has been appointed as senior finance director of the Group with effect from 1 February 2022.

Ms. Xiao, aged 40, joined the Group in January 2022 as senior director of the finance management division, in charge of the financial management, investment and financing matters of the Group. Prior to joining the Group, Ms. Xiao served as group chief financial officer of a multinational corporation specializing in the research and development and production of renewable energy solutions between June 2021 and October 2021.