VV Bio announced that preclinical and clinical data supporting the Company's novel platform and approach for treating acute myeloid leukemia (AML), will be presented at the 65th American Society of Hematology (ASH) Annual Meeting & Exposition, being held from December 9-12, 2023, in San Diego, CA. An abstract providing a clinical update from the VBP101 clinical trial (NCT048499910), a Phase 1/2a multicenter, open-label, first-in-human study of trem-cel (VOR33) in patients with AML, was accepted by ASH for oral presentation. This data supports robust neutrophil engraftment of trem-cel and provides evidence of hematologic protection from Mylotarg(TM), a CD33-targeted antibody drug conjugate.

An updated data release from VBP101 is expected by the Relapse After Transplant and Cellular Therapy (HSCT(2)) conference taking place November 10-11, 2023. CD33CART Study Clinical Data Update The Pediatric Transplantation and Cellular Therapy Consortium (PTCTC) released data providing a clinical update on a Phase 1/2 study of CD33CART (NCT03971799)(1), an autologous CAR-T therapy targeting CD33 (also referred to as VCAR33(AUTO) which uses the same CAR-T construct as VCAR33(A) (LLO). Nineteen pediatric and young adult patients with relapsed/refractory AML with a median age of 16 years were infused in the Phase 1 portion of the study.

Sarah K. Tasian, MD, is a co-investigator on the PTCTC-supported clinical trial and led the preclinical testing and translation of CD33CART with Terry Fry, MD, at the University of Colorado. Lastly, a trial-in-progress poster will be presented on the Company's VBP301 clinical trial, a Phase 1/2 multicenter, open- label, first-in-human trial of VCAR33(ALLO) in patients with relapsed or refractory AML after allogeneic stem cell transplantation.