LONDON--(BUSINESS WIRE)--

FORM 8.3 AMENDMENT TO PURCHASES

PUBLIC OPENING POSITION DISCLOSURE/DEALING DISCLOSURE BY

A PERSON WITH INTERESTS IN RELEVANT SECURITIES REPRESENTING 1% OR MORE

Rule 8.3 of the Takeover Code (the 'Code')

1. KEY INFORMATION

(a) Full name of discloser:

Barclays PLC.

(b) Owner or controller of interests and short positions disclosed, if different from 1(a):

The naming of nominee or vehicle companies is insufficient. For a trust, the trustee(s), settlor and beneficiaries must be named.

(c) Name of offeror/offeree in relation to whose relevant securities this form relates:

Use a separate form for each offeror/offeree

SHIRE PLC

(d) If an exempt fund manager connected with an offeror/offeree, state this and specify identity of offeror/offeree:
(e) Date position held/dealing undertaken:

For an opening position disclosure, state the latest practicable date prior to the disclosure

13 Sept 2018

(f) In addition to the company in 1(c) above, is the discloser making disclosures in respect of any other party to the offer?

If it is a cash offer or possible cash offer, state 'N/A'

YES: TAKEDA PHARMACEUTICAL CO LTD

2. POSITIONS OF THE PERSON MAKING THE DISCLOSURE

If there are positions or rights to subscribe to disclose in more than one class of relevant securities of the offeror or offeree named in 1(c), copy table 2(a) or (b) (as appropriate) for each additional class of relevant security.

(a) Interests and short positions in the relevant securities of the offeror or offeree to which the disclosure relates following the dealing (if any)

Class of relevant security: 5p ordinary
Interests Short Positions
Number (%) Number (%)
(1) Relevant securities owned
and/or controlled: 5,185,699 0.57% 1,618,779 0.18%
(2) Cash-settled derivatives:
247,298 0.03% 3,377,233 0.37%
(3) Stock-settled derivatives (including options)
and agreements to purchase/sell: 183,000 0.02% 260,800 0.03%
(4)
TOTAL: 5,615,997 0.61% 5,256,812 0.57%

All interests and all short positions should be disclosed.

Details of any open stock-settled derivative positions (including traded options), or agreements to purchase or sell relevant securities, should be given on a Supplemental Form 8 (Open Positions).

(b) Rights to subscribe for new securities (including directors' and other employee options)

Class of relevant security in relation to which subscription right exists:
Details, including nature of the rights concerned and relevant percentages:

3. DEALINGS (IF ANY) BY THE PERSON MAKING THE DISCLOSURE

Where there have been dealings in more than one class of relevant securities of the offeror or offeree named in 1(c), copy table 3(a), (b), (c) or (d) (as appropriate) for each additional class of relevant security dealt in.

The currency of all prices and other monetary amounts should be stated.

(a) Purchases and sales

Class of relevant Purchase/sale Number of Price per unit
security securities
5p ordinary Purchase 83 43.8911 GBP
5p ordinary Purchase 181 43.6100 GBP
5p ordinary Purchase 200 43.7500 GBP
5p ordinary Purchase 223 43.8561 GBP
5p ordinary Purchase 232 43.7935 GBP
5p ordinary Purchase 438 43.9629 GBP
5p ordinary Purchase 761 43.8671 GBP
5p ordinary Purchase 1,853 43.6657 GBP
5p ordinary Purchase 2,088 44.0468 GBP
5p ordinary Purchase 2,281 43.8053 GBP
5p ordinary Purchase 2,623 43.8387 GBP
5p ordinary Purchase 3,168 43.8995 GBP
5p ordinary Purchase 4,349 43.7576 GBP
5p ordinary Purchase 8,300 43.8957 GBP
5p ordinary Purchase 8,368 43.9000 GBP
5p ordinary Purchase 11,136 43.8107 GBP
5p ordinary Purchase 12,903 43.7572 GBP
5p ordinary Purchase 14,181 43.8429 GBP
5p ordinary Purchase 17,175 43.8332 GBP
5p ordinary Purchase 18,509 43.8983 GBP
5p ordinary Purchase 21,000 43.8100 GBP
5p ordinary Purchase 34,350 43.6801 GBP
5p ordinary Purchase 56,126 43.8248 GBP
5p ordinary Purchase 85,743 43.8397 GBP
5p ordinary Sale 29 43.8125 GBP
5p ordinary Sale 122 43.9550 GBP
5p ordinary Sale 147 43.8063 GBP
5p ordinary Sale 151 43.7050 GBP
5p ordinary Sale 198 44.0471 GBP
5p ordinary Sale 203 43.8207 GBP
5p ordinary Sale 300 43.8966 GBP
5p ordinary Sale 835 43.8331 GBP
5p ordinary Sale 903 43.8605 GBP
5p ordinary Sale 944 44.0532 GBP
5p ordinary Sale 1,055 43.8030 GBP
5p ordinary Sale 1,187 43.8912 GBP
5p ordinary Sale 1,526 43.9022 GBP
5p ordinary Sale 1,824 43.6162 GBP
5p ordinary Sale 2,075 43.7835 GBP
5p ordinary Sale 3,092 43.8093 GBP
5p ordinary Sale 3,300 43.7864 GBP
5p ordinary Sale 4,349 43.7576 GBP
5p ordinary Sale 5,870 43.8232 GBP
5p ordinary Sale 14,116 43.8429 GBP
5p ordinary Sale 18,048 43.9014 GBP
5p ordinary Sale 19,744 43.8360 GBP
5p ordinary Sale 40,342 43.8200 GBP
5p ordinary Sale 56,126 43.8248 GBP
5p ordinary Sale 70,908 43.8789 GBP
5p ordinary Sale 73,849 43.8374 GBP
ADR Purchase 60 172.0300 USD
ADR Purchase 68 172.5099 USD
ADR Purchase 100 172.0800 USD
ADR Purchase 100 172.2700 USD
ADR Purchase 200 172.0000 USD
ADR Purchase 236 172.4900 USD
ADR Purchase 300 172.6531 USD
ADR Purchase 310 172.3945 USD
ADR Purchase 500 172.4675 USD
ADR Purchase 600 172.1666 USD
ADR Purchase 916 172.5138 USD
ADR Purchase 1,283 172.3850 USD
ADR Purchase 1,400 172.4523 USD
ADR Purchase 1,480 172.3083 USD
ADR Purchase 1,500 172.3300 USD
ADR Purchase 1,900 172.4800 USD
ADR Purchase 3,000 172.2490 USD
ADR Purchase 4,400 172.3092 USD
ADR Purchase 10,000 172.6300 USD
ADR Purchase 10,000 172.2444 USD
ADR Purchase 12,100 172.3757 USD
ADR Sale 10 172.2100 USD
ADR Sale 60 172.0300 USD
ADR Sale 68 172.5099 USD
ADR Sale 100 172.1350 USD
ADR Sale 100 172.2800 USD
ADR Sale 100 172.1600 USD
ADR Sale 200 172.2300 USD
ADR Sale 200 172.0000 USD
ADR Sale 300 172.0833 USD
ADR Sale 300 172.5183 USD
ADR Sale 300 172.4366 USD
ADR Sale 400 172.3450 USD
ADR Sale 416 172.4900 USD
ADR Sale 700 172.1542 USD
ADR Sale 700 172.4357 USD
ADR Sale 800 172.4934 USD
ADR Sale 870 172.4220 USD
ADR Sale 1,400 172.3042 USD
ADR Sale 1,500 172.3300 USD
ADR Sale 1,500 172.5172 USD
ADR Sale 2,000 172.3285 USD
ADR Sale 2,200 172.3986 USD
ADR Sale 2,236 172.4800 USD
ADR Sale 3,900 172.2824 USD
ADR Sale 4,100 172.2939 USD
ADR Sale 6,383 172.3989 USD
ADR Sale 10,010 172.6300 USD
ADR Sale 16,000 172.3700 USD
ADR Sale 20,000 172.4372 USD
(b) Cash-settled derivative transactions
Class of Product Nature of dealing Number of Price per
relevant description reference unit
security securities
5p ordinary SWAP Long 249 43.8980 GBP
5p ordinary CFD Long 1,187 43.8912 GBP
5p ordinary CFD Long 1,526 43.9022 GBP
5p ordinary SWAP Long 2,744 43.9000 GBP
5p ordinary SWAP Long 4,526 43.7645 GBP
5p ordinary CFD Long 5,870 43.8232 GBP
5p ordinary CFD Long 9,724 43.7952 GBP
5p ordinary CFD Long 12,706 43.8964 GBP
ADR CFD Long 16,000 172.3700 USD
5p ordinary SWAP Long 16,827 43.9310 GBP
5p ordinary CFD Long 21,000 43.8075 GBP
5p ordinary SWAP Long 69,400 43.8378 GBP
5p ordinary CFD Short 36 43.8561 GBP
5p ordinary CFD Short 187 43.8562 GBP
5p ordinary CFD Short 232 43.7934 GBP
5p ordinary CFD Short 266 43.8410 GBP
5p ordinary CFD Short 438 43.9629 GBP
5p ordinary SWAP Short 556 43.8857 GBP
5p ordinary CFD Short 2,281 43.8053 GBP
5p ordinary CFD Short 2,623 43.8387 GBP
5p ordinary SWAP Short 3,241 43.8520 GBP
5p ordinary SWAP Short 5,152 43.9000 GBP
ADR CFD Short 7,000 169.3353 USD
5p ordinary CFD Short 11,136 43.8107 GBP
5p ordinary SWAP Short 17,175 43.8332 GBP
5p ordinary CFD Short 21,000 43.8100 GBP
5p ordinary SWAP Short 34,350 43.6801 GBP

(c) Stock-settled derivative transactions (including options)

(i) Writing, selling, purchasing or varying

Class Product Writing, Number Exercise Type Expiry Option
of description purchasing, of price date money
relevant selling, securities per unit paid/
security varying etc to which received
option per unit
relates
ADR Call Options Purchasing 100 185 USD American 19 Oct 2018 0.3200 USD
ADR Call Options Selling 100 180 USD American 19 Oct 2018 0.9200 USD

(ii) Exercise

Class of relevant security Product description

e.g. call option

Exercising/ exercised against Number of securities Exercise price per unit

(d) Other dealings (including subscribing for new securities)

Class of relevant security Nature of dealing

e.g. subscription, conversion

Details Price per unit (if applicable)

4. OTHER INFORMATION

(a) Indemnity and other dealing arrangements

Details of any indemnity or option arrangement, or any agreement or understanding, formal or informal, relating to relevant securities which may be an inducement to deal or refrain from dealing entered into by the person making the disclosure and any party to the offer or any person acting in concert with a party to the offer:

Irrevocable commitments and letters of intent should not be included. If there are no such agreements, arrangements or understandings, state 'none'

None

(b) Agreements, arrangements or understandings relating to options or derivatives

Details of any agreement, arrangement or understanding, formal or informal, between the person making the disclosure and any other person relating to:

(i) the voting rights of any relevant securities under any option; or

(ii) the voting rights or future acquisition or disposal of any relevant securities to which any derivative is referenced:

If there are no such agreements, arrangements or understandings, state 'none'

None

(c) Attachments

Is a Supplemental Form 8 (Open Positions) attached?

YES

Date of disclosure:

18 Sept 2018

Contact name:

Large Holdings Regulatory Operations

Telephone number:

020 3134 7213

Public disclosures under Rule 8 of the Code must be made to a Regulatory Information Service and must also be emailed to the Takeover Panel at monitoring@disclosure.org.uk. The Panel's Market Surveillance Unit is available for consultation in relation to the Code's disclosure requirements on +44 (0)20 7638 0129.

The Code can be viewed on the Panel's website at www.thetakeoverpanel.org.uk.

SUPPLEMENTAL FORM 8 (OPEN POSITIONS)

DETAILS OF OPEN STOCK-SETTLED DERIVATIVE (INCLUDING OPTION) POSITIONS, AGREEMENTS TO PURCHASE OR SELL ETC.

Note 5(i) on Rule 8 of the Takeover Code (the 'Code')

1. KEY INFORMATION

Full name of person making disclosure:

Barclays PLC.

Name of offeror/offeree in relation to whose relevant securities the disclosure relates:

SHIRE PLC

2. STOCK-SETTLED DERIVATIVES (INCLUDING OPTIONS)

Class Product Writing, Number Exercise Type Expiry
of description purchasing, of price date
relevant selling, securities per unit
security varying etc to which
option
relates
5p ordinary Call Options Written -125,000 3600.0000 American 21 Dec 2018
5p ordinary Put Options Written 125,000 3600.0000 American 21 Dec 2018
ADR Call Options Purchased 100 140.0000 American 18 Jan 2019
ADR Call Options Purchased 100 220.0000 American 18 Jan 2019
ADR Call Options Purchased 100 105.0000 American 18 Jan 2019
ADR Call Options Purchased 100 110.0000 American 17 Jan 2020
ADR Call Options Purchased 200 160.0000 American 17 Jan 2020
ADR Call Options Purchased 200 130.0000 American 17 Jan 2020
ADR Call Options Purchased 200 135.0000 American 17 Jan 2020
ADR Call Options Purchased 200 120.0000 American 17 Jan 2020
ADR Call Options Purchased 200 155.0000 American 17 Jan 2020
ADR Call Options Purchased 200 210.0000 American 18 Jan 2019
ADR Call Options Purchased 300 115.0000 American 18 Jan 2019
ADR Call Options Purchased 300 170.0000 American 14 Sep 2018
ADR Call Options Purchased 300 175.0000 American 18 Jan 2019
ADR Call Options Purchased 400 230.0000 American 18 Jan 2019
ADR Call Options Purchased 500 125.0000 American 18 Jan 2019
ADR Call Options Purchased 500 130.0000 American 19 Oct 2018
ADR Call Options Purchased 500 150.0000 American 18 Jan 2019
ADR Call Options Purchased 500 165.0000 American 18 Jan 2019
ADR Call Options Purchased 500 195.0000 American 18 Jan 2019
ADR Call Options Purchased 1,000 135.0000 American 18 Jan 2019
ADR Call Options Purchased 1,000 170.0000 American 17 Jan 2020
ADR Call Options Purchased 1,000 180.0000 American 17 Jan 2020
ADR Call Options Purchased 1,200 170.0000 American 18 Jan 2019
ADR Call Options Purchased 1,300 165.0000 American 19 Oct 2018
ADR Call Options Purchased 1,700 195.0000 American 17 Jan 2020
ADR Call Options Purchased 2,000 150.0000 American 17 Jan 2020
ADR Call Options Purchased 2,300 185.0000 American 18 Jan 2019
ADR Call Options Purchased 2,400 170.0000 American 19 Oct 2018
ADR Call Options Purchased 3,100 155.0000 American 18 Jan 2019
ADR Call Options Purchased 3,700 185.0000 American 19 Oct 2018
ADR Call Options Purchased 4,500 200.0000 American 18 Jan 2019
ADR Call Options Purchased 5,000 195.0000 American 19 Oct 2018
ADR Call Options Written -10,000 180.0000 American 18 Jan 2019
ADR Call Options Written -6,000 200.0000 American 17 Jan 2020
ADR Call Options Written -4,100 180.0000 American 19 Oct 2018
ADR Call Options Written -2,700 145.0000 American 18 Jan 2019
ADR Call Options Written -1,100 210.0000 American 19 Oct 2018
ADR Call Options Written -1,000 85.0000 American 18 Jan 2019
ADR Call Options Written -900 175.0000 American 19 Oct 2018
ADR Call Options Written -800 160.0000 American 19 Oct 2018
ADR Call Options Written -500 160.0000 American 18 Apr 2019
ADR Call Options Written -100 140.0000 American 17 Jan 2020
ADR Call Options Written -100 145.0000 American 19 Oct 2018
ADR Call Options Written -100 130.0000 American 18 Jan 2019
ADR Call Options Written -100 173.0000 American 12 Oct 2018
ADR Call Options Written -100 173.0000 American 21 Sep 2018
ADR Put Options Purchased -44,000 145.0000 American 19 Oct 2018
ADR Put Options Purchased -8,900 135.0000 American 18 Jan 2019
ADR Put Options Purchased -8,600 170.0000 American 19 Oct 2018
ADR Put Options Purchased -6,600 165.0000 American 19 Oct 2018
ADR Put Options Purchased -5,800 180.0000 American 18 Jan 2019
ADR Put Options Purchased -4,600 155.0000 American 18 Jan 2019
ADR Put Options Purchased -3,700 145.0000 American 17 Jan 2020
ADR Put Options Purchased -2,700 80.0000 American 18 Jan 2019
ADR Put Options Purchased -2,500 120.0000 American 17 Jan 2020
ADR Put Options Purchased -2,300 85.0000 American 18 Jan 2019
ADR Put Options Purchased -2,100 160.0000 American 18 Jan 2019
ADR Put Options Purchased -2,000 175.0000 American 19 Oct 2018
ADR Put Options Purchased -1,800 115.0000 American 18 Jan 2019
ADR Put Options Purchased -1,500 165.0000 American 18 Jan 2019
ADR Put Options Purchased -1,200 135.0000 American 17 Jan 2020
ADR Put Options Purchased -1,100 150.0000 American 19 Oct 2018
ADR Put Options Purchased -1,000 170.0000 American 17 Jan 2020
ADR Put Options Purchased -1,000 80.0000 American 17 Jan 2020
ADR Put Options Purchased -1,000 140.0000 American 18 Jan 2019
ADR Put Options Purchased -1,000 105.0000 American 18 Jan 2019
ADR Put Options Purchased -1,000 150.0000 American 18 Jan 2019
ADR Put Options Purchased -800 150.0000 American 17 Jan 2020
ADR Put Options Purchased -700 160.0000 American 17 Jan 2020
ADR Put Options Purchased -500 155.0000 American 19 Oct 2018
ADR Put Options Purchased -500 140.0000 American 17 Jan 2020
ADR Put Options Purchased -400 165.0000 American 17 Jan 2020
ADR Put Options Purchased -400 145.0000 American 18 Jan 2019
ADR Put Options Purchased -200 115.0000 American 19 Oct 2018
ADR Put Options Purchased -200 170.0000 American 18 Jan 2019
ADR Put Options Purchased -100 163.0000 American 14 Sep 2018
ADR Put Options Written 100 140.0000 American 19 Oct 2018
ADR Put Options Written 100 110.0000 American 18 Jan 2019
ADR Put Options Written 100 110.0000 American 17 Jan 2020
ADR Put Options Written 100 95.0000 American 18 Jan 2019
ADR Put Options Written 100 75.0000 American 19 Oct 2018
ADR Put Options Written 200 70.0000 American 19 Oct 2018
ADR Put Options Written 200 200.0000 American 17 Jan 2020
ADR Put Options Written 200 125.0000 American 19 Oct 2018
ADR Put Options Written 200 100.0000 American 18 Jan 2019
ADR Put Options Written 500 125.0000 American 18 Jan 2019
ADR Put Options Written 1,000 155.0000 American 5 Oct 2018
ADR Put Options Written 1,000 90.0000 American 18 Jan 2019
ADR Put Options Written 1,000 160.0000 American 21 Sep 2018
ADR Put Options Written 2,300 130.0000 American 18 Jan 2019
ADR Put Options Written 5,300 120.0000 American 18 Jan 2019
ADR Put Options Written 10,000 160.0000 American 0 Jan 1900

3. AGREEMENTS TO PURCHASE OR SELL ETC.

Full details should be given so that the nature of the interest or position can be fully understood:

It is not necessary to provide details on a Supplemental Form (Open Positions) with regard to cash-settled derivatives.

The currency of all prices and other monetary amounts should be stated.

The Panel's Market Surveillance Unit is available for consultation in relation to the Code's disclosure requirements on +44 (0)20 7638 0129.

The Code can be viewed on the Panel's website atwww.thetakeoverpanel.org.uk.

View source version on businesswire.com:https://www.businesswire.com/news/home/20180918005503/en/

BARCLAYS PLC

Source: BARCLAYS PLC

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Barclays plc published this content on 18 September 2018 and is solely responsible for the information contained herein. Distributed by Public, unedited and unaltered, on 18 September 2018 11:32:03 UTC