The pan-European STOXX 600 index slipped 0.1%, failing to match Wall Street gains on signs that U.S. lawmakers were making progress on a $2.2 trillion stimulus package that could be voted on next week.
The index shed 3.6% in a week dominated by concerns about new coronavirus restrictions in Europe, a faltering stock rally in Wall Street's technology giants and worrying economic data from both sides of the Atlantic.
France and Britain set new records of daily COVID-19 infections on Thursday, while the Spanish government recommended reimposing a partial lockdown on all of the city of Madrid after the country surpassed 700,000 cases, the highest number in Western Europe.
"New restrictions in Europe, less fiscal support, fading liquidity impulse and election risk should weigh on activity in Q4," European equity strategists at Barclays wrote in a note. "Economic surprises are starting to roll over from all-time high levels."
European banks <.SX7P> sank to a fresh record low as investors shunned the sector hit by a cocktail of lower global borrowing costs, rising bad loans due to the economic downturn and dirty money scandal that made it the worst performer this week.
Graphic: European bank stocks vs the broader market
British betting firm William Hill surged 43.5% after revealing that it had received rival takeover proposals from buyout firm Apollo and U.S. casino operator Caesars Entertainment.
Ladbrokes and bwin brand owner GVC jumped 16.7% and Paddy Power owner Flutter Entertainment gained 6.8%, helping reverse early losses in travel & leisure stocks, which were up 3.2%.
Still, worries about new travel restrictions weighed on airlines, with British Airways-owner IAG, Lufthansa and Air France KLM down between 0.6% and 3.3%.
Automakers fell 1.4% after an industry body said British car production fell by an annual 45% in August, as the sector continues to suffer due to the fallout from the virus outbreak.
Paris Match publisher Lagardere surged 32.3% after billionaire Bernard Arnault revealed he had built up a direct stake in the firm, which is under siege from several other investors.
Swedish home appliance maker Electrolux rose 2.9% after saying that it would propose reinstating dividends after a recovery in earnings and cash flows during the third quarter.
By Sruthi Shankar