Log in
E-mail
Password
Remember
Forgot password ?
Become a member for free
Sign up
Sign up
New member
Sign up for FREE
New customer
Discover our services
Settings
Settings
Dynamic quotes 
OFFON

MarketScreener Homepage  >  Equities  >  Nasdaq  >  Adaptive Biotechnologies Corporation    ADPT

ADAPTIVE BIOTECHNOLOGIES CORPORATION

(ADPT)
  Report
SummaryQuotesChartsNewsRatingsCalendarCompanyFinancialsConsensusRevisions 
SummaryAll NewsPress ReleasesOfficial PublicationsSector news

Focus: Next big COVID-19 treatment may be manufactured antibodies

share with twitter share with LinkedIn share with facebook
08/03/2020 | 07:33pm EDT
FILE PHOTO: A man walks past a sign at an AstraZeneca site in Macclesfield

As the world awaits a COVID-19 vaccine, the next big advance in battling the pandemic could come from a class of biotech therapies widely used against cancer and other disorders - antibodies designed specifically to attack this new virus.

Development of monoclonal antibodies to target the virus has been endorsed by leading scientists. Anthony Fauci, the top U.S. infectious diseases expert, called them "almost a sure bet" against COVID-19.

When a virus gets past the body's initial defenses, a more specific response kicks in, triggering production of cells that target the invader. These include antibodies that recognize and lock onto a virus, preventing the infection from spreading.

Monoclonal antibodies - grown in bioreactor vats - are copies of these naturally-occurring proteins.

Scientists are still working out the exact role of neutralizing antibodies in recovery from COVID-19, but drugmakers are confident that the right antibodies or a combination can alter the course of the disease that has claimed more than 675,000 lives globally.

"Antibodies can block infectivity. That is a fact," Regeneron Pharmaceuticals executive Christos Kyratsous told Reuters.

Regeneron is testing a two-antibody cocktail, which it believes limits the ability of the virus' to escape better than one, with data on its efficacy expected by late summer or early fall. "Protection will wane over time. Dosing is something we don't know yet," said Kyratsous.

The U.S. government in June awarded Regeneron a $450 million supply contract. The company said it can immediately begin production at its U.S. plant if regulators approve the treatment.

Eli Lilly and Co <LLY.N, AstraZeneca, Amgen, and GlaxoSmithKline were cleared by the U.S. government to pool manufacturing resources in order to scale up supplies if any of these drugs prove successful.

Even with that unusual cooperation among rivals, manufacturing these medicines is complex and capacity is limited. There is also a debate over whether a single antibody will be powerful enough to stop COVID-19.

AstraZeneca said it plans to start human trials of its dual-antibody combination within weeks.

Lilly, which began human testing in June of two antibody candidates in separate trials, is focusing on a one-drug approach.

"If you need a higher dosage or more antibodies, fewer people can be treated," Lilly Chief Scientific Officer Dan Skovronsky said.

'INSTANT IMMUNITY'

Unlike vaccines, which activate the body's own immune system, the impact of infused antibodies eventually dissipates.

Still, drugmakers say monoclonal antibodies could temporarily prevent infection in at-risk people such as medical workers and the elderly. They could also be used as a therapeutic bridge until vaccines become widely available.

"In a prophylactic setting we think we may achieve coverage for up to six months," said Phil Pang, chief medical officer of Vir Biotechnology, which aims to start testing an antibody in non-hospitalized patients next month with partner GSK.

"The advantage of an antibody is that it is basically instant immunity," said Mark Brunswick, senior vice president at Sorrento Therapeutics, which aims to begin human trials next month of a single antibody candidate.

Safety risks for monoclonal antibodies are considered low, but their cost can be quite high. These type of drugs for cancer can cost over $100,000 a year.

There is also concern that the coronavirus could become resistant to specific antibodies. Researchers are already at work on second-generation compounds with targets other than the crown-like spikes the virus uses to invade cells.

"We are trying to develop something that is complementary," Amgen research chief David Reese said. Amgen is working with Adaptive Biotechnologies Corp.

Researchers in a recent paper published in the journal Nature said they had discovered several new, very potent, antibodies directed to an area where the virus attaches to human cells and to a region of the spike that has not attracted attention.

"To avoid development of resistance you want to target different sites," study author and Columbia University professor David Ho told Reuters.

There are also questions about when in the course of the illness it might be best to employ these new weapons. "Giving an antibody later on after infection might not be that helpful, said Florian Krammer, microbiology professor at New York's Icahn School of Medicine. "Given early, they probably work well."

By Deena Beasley

Stocks mentioned in the article
ChangeLast1st jan.
ADAPTIVE BIOTECHNOLOGIES CORPORATION -0.68% 48.04 Delayed Quote.60.56%
AMGEN INC. 0.51% 248.3 Delayed Quote.3.00%
ASTRAZENECA PLC -0.13% 8539 Delayed Quote.12.25%
ELI LILLY AND COMPANY -1.24% 146.26 Delayed Quote.11.28%
GLAXOSMITHKLINE PLC -0.56% 1455 Delayed Quote.-18.18%
REGENERON PHARMACEUTICALS 0.30% 573.61 Delayed Quote.52.77%
SORRENTO THERAPEUTICS, INC. 14.29% 11.6 Delayed Quote.243.20%
VIR BIOTECHNOLOGY, INC. 4.31% 37.73 Delayed Quote.200.04%
share with twitter share with LinkedIn share with facebook
All news about ADAPTIVE BIOTECHNOLOGIES CORPORATION
09/01Adaptive Biotechnologies to Present at the Morgan Stanley 2020 Healthcare Con..
GL
08/21ADAPTIVE BIOTECHNOLOGIES CORP : Other Events, Financial Statements and Exhibits ..
AQ
08/11ADAPTIVE BIOTECHNOLOGIES : to Present at the UBS Genomics 2.0 and Medtech Innova..
AQ
08/10ADAPTIVE BIOTECHNOLOGIES : 2Q Earnings Snapshot
AQ
08/10ADAPTIVE BIOTECHNOLOGIES : Management's Discussion and Analysis of Financial Con..
AQ
08/10ADAPTIVE BIOTECHNOLOGIES CORP : Results of Operations and Financial Condition, F..
AQ
08/10Adaptive Biotechnologies Reports Second Quarter 2020 Financial Results
GL
08/10Adaptive Biotechnologies to Present at the UBS Genomics 2.0 and Medtech Innov..
GL
08/07ADAPTIVE BIOTECHNOLOGIES : Receives Expanded FDA Clearance for the clonoSEQ Assa..
AQ
08/06ADAPTIVE BIOTECHNOLOGIES : Receives Expanded FDA Clearance for the clonoSEQ® Ass..
AQ
More news
Financials (USD)
Sales 2020 95,9 M - -
Net income 2020 -140 M - -
Net cash 2020 377 M - -
P/E ratio 2020 -44,4x
Yield 2020 -
Capitalization 6 524 M 6 524 M -
EV / Sales 2020 64,1x
EV / Sales 2021 35,5x
Nbr of Employees 453
Free-Float 94,4%
Chart ADAPTIVE BIOTECHNOLOGIES CORPORATION
Duration : Period :
Adaptive Biotechnologies Corporation Technical Analysis Chart | MarketScreener
Full-screen chart
Technical analysis trends ADAPTIVE BIOTECHNOLOGIES CORPORATION
Short TermMid-TermLong Term
TrendsBullishBullishBullish
Income Statement Evolution
Consensus
Sell
Buy
Mean consensus BUY
Number of Analysts 7
Average target price 51,80 $
Last Close Price 48,04 $
Spread / Highest target 31,1%
Spread / Average Target 7,83%
Spread / Lowest Target -12,6%
EPS Revisions
Managers
NameTitle
Chad Robins Chairman & Chief Executive Officer
Julie Rubinstein President
Nancy L. Hill Senior Vice President-Operations
Chad M. Cohen CFO, Principal Financial & Accounting Officer
Harlan Robins Chief Scientific Officer
Sector and Competitors
1st jan.Capitalization (M$)
ADAPTIVE BIOTECHNOLOGIES CORPORATION60.56%6 524
EXACT SCIENCES CORPORATION7.81%15 319
GUARDANT HEALTH, INC.42.36%11 060
BGI GENOMICS CO., LTD.107.76%8 295
INVITAE CORPORATION174.58%5 837
SEEGENE INC--.--%5 790