Sanjay Keswani, MBBS, FRCP, Executive Vice President and Chief Medical Officer (“CMO”) of Annexon, Inc. (the “Company”), has resigned his position effective February 23, 2022 in order to tend to personal obligations in the United Kingdom. The Company is engaged in a search for a new CMO, and Henk-André Kroon, MD, Senior Vice President of Translational Medicine, will assume responsibility for the Company's clinical development programs on an interim basis.