Aptinyx Inc. announced the completion of enrollment of 99 patients in the company's ongoing Phase 2 study of NYX-458 in cognitive impairment associated with Parkinson's disease and dementia with Lewy bodies. Patients recently enrolled in the study are completing the 12-week treatment period and 30-day safety follow-up period. The company expects to report results from the study in First Quarter 2023.

The Phase 2 study is a randomized, double-blind, parallel-design, placebo-controlled study to evaluate the safety and potential cognitive benefits of NYX-458 in 99 patients with mild cognitive impairment or mild dementia associated with Parkinson's disease or dementia with Lewy bodies. The study evaluates daily oral dosing of a 30 mg dose level of NYX-458 compared to placebo over a 12-week period. The study assesses the overall safety and tolerability of NYX-458 in patients, as well as its effects across multiple neurocognitive endpoints focused on attention, memory, and executive function.