On June 30, 2023, Robert Hombach notified Aptinyx Inc. of his resignation as a member of the Company’s board of directors, effective immediately. Mr. Hombach’s resignation did not result from any disagreement with the Company on any matter relating to the Company’s operations, policies or practices. On June 30, 2023, Andrew Kidd, stepped down from his position as principal accounting officer of the Company.

On June 30, 2023, following Mr. Kidd’s resignation, Craig Jalbert was appointed principal accounting officer of the Company.