Aptinyx Inc. announced that following the approval of the Plan of Dissolution by the Board, on May 4, 2023, Henry O. Gosebruch, Terry Gould, Adam M. Koppel, Joan W. Miller, Rachel E. Sherman, Norbert G. Riedel, and Andrew Kidd, each notified the Company of their respective resignations as members of the Company's board of directors, effective immediately. The resignations of Henry O. Gosebruch, Terry Gould, Adam M. Koppel, Joan W. Miller, Rachel E. Sherman, Norbert G. Riedel, and Andrew Kidd from the Company's board of directors were not due to any disagreements with the Company on any matters relating to the Company's operations, policies or practices. Each of Andy Kidd, principal executive officer of the Company, Ashish Khanna, Chief Business Officer, principal financial officer and principal accounting officer of the Company, and Norbert Riedel, Executive Chairman of the Company, has agreed on a separation from the Company effective as of May 5, 2023.

In connection with the approval of the Plan of Dissolution, the Board appointed Craig Jalbert, age 61, as the Company's President, Treasurer, Corporate Secretary, effective May 5, 2023, and a Class I director, effective May 4, 2023. The term of the Company's Class I directors, including Mr. Jalbert, expires on the date of the Company's annual meeting of stockholders to be held in 2025 or upon the election and qualification of successor directors. Mr. Jalbert has not been appointed to any committee of the Board and as of the date hereof is not expected to be appointed to any committee of the Board.

Mr. Jalbert has served as a principal of the Foxborough, Massachusetts accounting firm of Verdolino & Lowey, P.C. since 1987. For over 30 years he has focused his practice in distressed businesses and has served, and continues to serve, in the capacities of officer and director for numerous firms in their wind-down phases.